多巴胺在颅内动脉瘤栓塞术麻醉中的应用  

Application of Dopamine in Anesthesia of Endovascular Embolization for Intracranial Aneurysm

作　　者：车军[1] 金炳植[1] 

机构地区：[1]延边大学附属医院,吉林延边133000

出　　处：《中国医药指南》2015年第9期24-25,共2页Guide of China Medicine

摘　　要：目的评价多巴胺静脉泵注在颅内动脉瘤栓塞术麻醉中的效果。方法择期行颅内动脉瘤栓塞术的ASA分级Ⅱ~Ⅲ级患者40例,随机分为多巴胺组和对照组,每组20例。多巴胺组术中静脉泵注多巴胺2~4μg/（kg？min）,对照组静脉泵注同等容量生理盐水。每组以丙泊酚静脉泵注4 mg/（kg？h）,瑞芬太尼6μg/（kg？h）麻醉维持,术中静脉泵注尼莫地平2~4μg/（kg？min）,并维持平均动脉压60~75 mm Hg。观察两组麻醉医师暴露在放射线下的时间,麻醉时间及拔管时间。结果多巴胺组术中麻醉医师暴露在放射线下的时间明显少于对照组（P〈0.05）,两组麻醉时间及拔管时间无显著差异（P〉0.05）。结论多巴胺静脉泵注用于颅内动脉瘤栓塞术麻醉,血流动力学更平稳,能减少麻醉医师暴露在放射线下的时间。Objective To evaluate the effectiveness of dopamine in anesthesia of endovascular embolization for intracranial aneurysm. Methods 40 ASA Ⅱ-Ⅲ patients of intracranial aneurysm, scheduled endovascular embolization, were randomly divided into two groups（n=20 each）： dopamine group and control group. Dopamine was intravenously infused at 2-4 μg/（kg·min） in dopamine group, while the equal volume of normal saline was infused in control group during operation. Anesthesia of each group was maintained by intravenously infusing propofol 4 mg/（kg·h）, remifentanil 6 μg/（kg·h） and nimodipinum was intravenously infused at 2-4 μg/（kg·min）, MAP was maintained 60-75 mm Hg during operation. Then the time anesthesiologists were exposed to radiation, the time of anesthesia and extubation were recorded. Results The time anesthesiologists were exposed to radiation, was significantly decreased in dopamine group than that in control group（P〈0.05）, there were no significant difference in the time of anesthesia and extubation between two group. Conclusion Application of dopamine can maintain more stable hemodynamics and decrease the time anesthesiologists were exposed to radiation, in anesthesia of endovascular embolization for intracranial aneurysm.

关 键 词：多巴胺 全身麻醉 颅内动脉瘤栓塞术 

分 类 号：R614[医药卫生—麻醉学]