Micromechanical properties of poly(N-isopropylacrylamide)hydrogel microspheres determined using a simple method  

作　　者：Mei Yuan Xiaojie Ju Rui Xie Wei Wang Liangyin Chu 

机构地区：[1]School of Chemical Engineering,Sichuan University

出　　处：《Particuology》2015年第2期164-172,共9页颗粒学报（英文版）

基　　金：support from the National Natural Science Foundation of China(21136006,21276002,21322605);the Program for New Century Excellent Talents in University(NCET-12-0376);the National High Technology Research and Development Program(863 Program)(2012AA021403);the Foundation for the Authors of National Excellent Doctoral Dissertations of China(201163)

摘　　要：Temperature-responsive poly（N-isopropylacrylamide） （PNIPAM） hydrogel microspheres have attracted extensive attention because of their promising diverse biomedical applications. A quantitative understanding of the micromechanical properties of these microspheres is essential for their practical application. Here, we report a simple method for the characterization of the elastic properties of PNIPAM hydrogel microspheres. The results show that PNIPAM hydrogel microspheres exhibit elastic deformation and the obtained force-deformation experimental data fits the Hertz theory well. The moduli of elasticity of the PNIPAM hydrogel microspheres prepared under different conditions were systematically investigated in this work for the first time. The PN1PAM hydrogel microsphere composition significantly affects their micromechanical properties and their temperature sensitivity behavior. PNIPAM hydrogel microspheres with a larger equilibrium volume change have a lower modulus of elasticity. The modulus of elasticity of the PNIPAM hydrogel microspheres at body temperature （37 ℃, above the lower critical solution temperature （LCST） of PNIPAM） is much higher than that at room temperature （25 ℃, below the LCST of PNIPAM） because ofthermo-induced volume shrinkage and an increase in stiffness. These results provide valuable guidance for the design of smart materials for practical biomedical applications. Moreover, the simple microcompression method presented here also provides a versatile way to investigate the micromechanical properties of microscopic biomedical materials.Temperature-responsive poly（N-isopropylacrylamide） （PNIPAM） hydrogel microspheres have attracted extensive attention because of their promising diverse biomedical applications. A quantitative understanding of the micromechanical properties of these microspheres is essential for their practical application. Here, we report a simple method for the characterization of the elastic properties of PNIPAM hydrogel microspheres. The results show that PNIPAM hydrogel microspheres exhibit elastic deformation and the obtained force-deformation experimental data fits the Hertz theory well. The moduli of elasticity of the PNIPAM hydrogel microspheres prepared under different conditions were systematically investigated in this work for the first time. The PN1PAM hydrogel microsphere composition significantly affects their micromechanical properties and their temperature sensitivity behavior. PNIPAM hydrogel microspheres with a larger equilibrium volume change have a lower modulus of elasticity. The modulus of elasticity of the PNIPAM hydrogel microspheres at body temperature （37 ℃, above the lower critical solution temperature （LCST） of PNIPAM） is much higher than that at room temperature （25 ℃, below the LCST of PNIPAM） because ofthermo-induced volume shrinkage and an increase in stiffness. These results provide valuable guidance for the design of smart materials for practical biomedical applications. Moreover, the simple microcompression method presented here also provides a versatile way to investigate the micromechanical properties of microscopic biomedical materials.

关 键 词：Poly（N-isopropylacrylamide） MICROSPHERES Micromechanical properties Modulus of elasticity Temperature-responsive volume change Lower critical solution temperature 

分 类 号：TQ427.26[化学工程]