联合疫苗接种对反复呼吸道感染患儿细胞免疫功能的影响与疗效  

Combined vaccination in treatment of children with recurrent respiratory tract infection and influence on cellular immunologic function

作　　者：李晓岚[1] 李晓军[1] 柳肖 谢帆 

机构地区：[1]武汉市汉口医院儿科,湖北武汉430012 [2]武汉市江岸区金桥社区卫生服务中心,湖北武汉430014

出　　处：《临床荟萃》2015年第4期387-389,共3页Clinical Focus

基　　金：武汉市卫生局公共卫生科研项目(WG-10C11)

摘　　要：目的观察肺炎球菌疫苗与流感疫苗联合接种对反复呼吸道感染(RRTI)患儿细胞免疫及疗效的影响。方法将80例RRTI患儿随机分为对照组,联合接种肺炎球菌疫苗与流感疫苗组(联合接种组),肺炎球菌疫苗组、流感疫苗组;同时选取同期治疗的非RRTI的急性呼吸道感染患儿(非RRTI组)30例。观察各组患儿细胞免疫功能变化及临床疗效。结果与非RRTI组比较,RRTI组血清CD4+水平和CD4+/CD8+比值明显降低,而CD8+水平明显升高;治疗12周后,与对照组比较,肺炎球菌疫苗组、流感疫苗组和联合接种组患儿血清CD4+水平和CD4+/CD8+比值明显上升,而CD8+水平明显下降(P<0.01);与对照组比较,肺炎球菌疫苗组、流感疫苗组和联合接种组患儿总有效率明显上升(85.0%、80.0%、95.0%vs 10.0%)(P<0.01);治疗期间无药物不良反应事件。结论肺炎球菌疫苗与流感疫苗联合接种可有效改善RRTI患儿的细胞免疫功能,疗效肯定。Objective To observe the effects of combined vaccination in the treatment of children with recurrent respiratory tract infection（RRTI）and its influence on cellular immunologic function.Methods A total of 80 cases with RRTI were randomly divided into four groups,including control group with placebo treatment,combined group with treatment of pneumococcus and influenza vaccines,pneumococcus vaccine group and influenza vaccine group.The changes of cell immune function and clinical effect were investigated in four groups as well as 30 children of non-RRTI acute respiratory tract infection.Results The serum level of CD4＋and the ratio of CD4＋to CD8＋were significantly lower in RRTI group than in non-RRTI group,however,the serum level of CD8＋was significantly higher in RRTI group than in non-RRTI group.Compared with the control group,the serum level of CD4＋and the ratio of CD4＋to CD8＋were significantly increased in combined group,pneumococcus vaccine group and influenza vaccine group,however,the serum level of CD8＋was significantly lower,after 12 weeks＇ treatment（P〈 0.01）.The efficiency of inoculation in pneumococcus vaccine group,influenza vaccine group and combined group was significantly increased than that of the control group（85.0%,80.0%,95.0% vs 10.0%,respectively）（P〈 0.01）.No drug adverse events occurred during treatment.Conclusion Combined inoculation of pneumococcal vaccine and influenza vaccine can effectively improve the cellular immune function and curative effect in children with RRTI.

关 键 词：呼吸道感染 肺炎球菌菌苗 流感疫苗 免疫 细胞 

分 类 号：R517.6[医药卫生—内科学]