2-氟丙烯酸甲酯的制备  

Synthesis of 2-Fluorinated Methyl Acrylate

作　　者：陈剑君[1] 王玉林[1] 吴雪妹[1] 吾国强[1] 王树华 周强 陶晓红[1] 朱成红 吕亮[1] 

机构地区：[1]衢州学院化学与材料工程学院,324000 [2]巨化集团技术中心,国家氟材料工程技术研究中心,324004 [3]衢州新诺高分子材料有限公司,浙江衢州324002

出　　处：《化工生产与技术》2015年第1期10-12,7,共3页Chemical Production and Technology

基　　金：浙江省重点技术创新项目(2014183);浙江省科技厅公益性项目(2013C31108;2013C33018);衢州市科技计划项目(20111047;20111051;2013Y11);衢州学院科研基金重点项目(KZZ1101)

摘　　要：以2-氯丙酸甲酯为起始原料,经氟代、溴化、消除反应得2-氟代丙烯酸甲酯。研究了条件对氟代、溴化反应的影响。结果表明,氟化反应优化条件为:n(KF):n(C4H7ClO2)为1.3:l,溶剂用量为45mL,反应温度180℃,氟化反应产率达到92.2%;溴化反应优化条件为:n(NBS):n(C4H7FO2)为1.2:l,溶剂DMF用量为100mL,引发剂用量为6g,溴代反应产率为81.9%。总收率可达40%以上,具有一定的工业化应用前景。2-Fluorinated methyl acrylate was produced through fluorination, bromination and elimination reaction using 2-chloropropionic acid methyl ester as the raw material, studied the influence of reaction conditions on fluorination and bromination reaction. The results showed that the optimized fluorination conditions were: molar ratio of KF and C4H7 Cl O2was 1.3: l, of solvent dosage was 45 mL, reaction temperature was 180 ℃, reaction yield reached 92.2%; the optimized bromination conditions were: molar ratio of NBS and C4H7FO2 was 1.2: l, solvent(DMF) dosage was 100 m L, initiator dosage was 6g, reaction yield was 81.9%. Total yield could reach more than 40%, had certain application prospect of industrialization.

关 键 词：2-氟丙烯酸酯 2-氟丙酸酯 氟代 溴代 

分 类 号：TQ225.24[化学工程—有机化工]