花生四烯酸CYP表氧化酶代谢产物EET对心肌病的保护作用  

Arachidonic acid CYP epoxygenase metabolites EET and cardiomyopathy

作　　者：周冰[1] 何淑兰[1] 谭武红[1] 

机构地区：[1]西安交通大学医学部微量元素与地方病卫生部重点实验室,环境与疾病相关基因教育部重点实验室,陕西西安710061

出　　处：《国外医学（医学地理分册）》2015年第1期66-70,共5页Foreign Medical Sciences：Section of Medgeography

摘　　要：心肌病发病率有逐年升高的趋势,花生四烯酸及其表氧化酶代谢产物环氧二十碳三烯酸(EETs)在心肌疾病中具有重要的生理病理作用,如抗心肌缺血、抗炎症反应、改善内皮功能、抗血小板黏附与聚集等作用,可作用于多种心血管细胞的离子通道,也可调节凋亡相关基因和蛋白的表达,从而起到心肌保护作用。本文对EETs的产生途径以及对心肌的保护作用及机制加以阐述。The incidence of cardiomyopathy has showed an increasing trend. Arachidonic acid and the epoxygenase product,epoxyeicosatrienoic acids （EETs）,have important physiological and pathological roles,such as anti-myocardial ischemia and anti-inflammation effects.Besides,they can improve endothelial function,platelet adhesion and aggregation.EETs can be applied to a variety of ion channels of cardiovascular cells,and protect myocardial by regulating the expression of genes and proteins related to apoptosis.This review summarized the pathway of EETs and its protective effect and mechanism on myocardium.

关 键 词：花生四烯酸 细胞色素P450 环氧二十碳三烯酸 心肌病 

分 类 号：R542[医药卫生—心血管疾病]