银杏达莫注射液抗慢性胰腺炎纤维化的作用  

The Anti-fibrosis Effect of YinXing DaMo Injection on Chronic Pancreatitis

作　　者：班志勇[1] 韦桂莲[1] 黄谢梅[1] 

机构地区：[1]河池市人民医院,广西河池547000

出　　处：《西部中医药》2015年第2期105-107,共3页Western Journal of Traditional Chinese Medicine

摘　　要：目的:探讨外周血转化生长因子(TGF-β1)浓度及高凝状态与慢性胰腺炎(CP)纤维化的关系,同时研究银杏达莫注射液对抗慢性胰腺炎纤维化的作用。方法:将50例CP患者随机分为观察组、对照组各25例。2组均给予戒烟、低脂高蛋白饮食、避免饱食等常规治疗,观察组同时予银杏达莫注射液静脉滴注,1次/d。2组连续治疗2周,观察2组治疗前后TGF-β1、凝血及血脂、血液流变学等指标的变化情况。结果:外周血TGF-β1浓度、生化指标、凝血指标、血液流变学指标2组治疗后均明显改善(P<0.05),观察组改善更明显(P<0.05)。结论:外周血TGF-β1与CP纤维化相关,银杏达莫能够抑制外周血TGF-β1表达,同时能改善CP患者血液高凝状态,有利于改善慢性胰腺炎纤维化进展。Objective：To discuss relations between chronic pancreatitis （CP） and the concentration as well as hypercoagulability of TGF-β1 in peripheral blood and to study the anti-fibrosis effect of YinXingDaMo injection on CP. Methods：The 50 CP patients were randomized into observation and control groups with 25 cases in each. Both groups given the conventional treatment of quitting smoking, supplementing low-protein diet and avoiding engorge-ment, the observation groups were intravenously injected YinXing DaMo for once a day. After 2-week continual treatment, the indexes changes of TGF-β1, blood coagulation and lipids and hemorheology before and after treatment were observed. Results：The indexes of the concentration of TGF-β1 in peripheral blood, biochemistry, coagulation and hemorheology in both groups were all improved significantly （P〈0.05）, and those indexes in observation group were improved more significantly （P〈0.05）. Conclusion：The TGF-β1 in peripheral blood is associated with CP fi-brosis and the YinXing DaMo injection can inhibit the expression of TGF-β1 and improve the hypercoagulability of CP patients to meliorate the fibrosis development of CP.

关 键 词：胰腺炎 慢性 银杏达莫 TGF-Β1 高凝状态 

分 类 号：R259[医药卫生—中西医结合]