P(γ-PGA-co-NIPAAm)水凝胶对5-氟尿嘧啶药物分子的释放行为  

Release Behavior of 5-Fluorouracil Drug Molecules from P(γ-PGA-co-NIPAAm)Hydrogels

作　　者：张鲁杰[1] 郭义兵[1] 石璐[1] 王凤志[1] 杨宁[1] 陈莉[1] 

机构地区：[1]天津工业大学材料科学与工程学院,天津300387

出　　处：《功能高分子学报》2015年第1期91-96,共6页Journal of Functional Polymers

基　　金：国家自然科学基金(31200719);国家级大学生创新创业训练计划项目(201310058011)

摘　　要：以γ-聚谷氨酸（γ-PGA）、N-异丙基丙烯酰胺（NIPAAm）为单体,通过自由基共聚法制备一种水凝胶缓释材料。采用扫描电镜观察水凝胶的多孔断面形貌,并研究不同温度（25℃和37℃）下水凝胶表面的亲疏水性和不同pH（2.0-10.0）时的溶胀率变化。将该共聚水凝胶用作药物缓释载体,通过紫外分光光度计法研究其对5-氟尿嘧啶（5-FU）药物分子的缓释行为。结果表明：该凝胶在酸性条件下释药速率最快,碱性条件下次之,中性条件下释放最慢,25℃下释放量与γ-PGA含量呈正相关,37℃下结果相反;该凝胶具有温度、pH双敏感性,在弱碱性条件下释放缓慢、释药量小,具有一定的靶向释药能力。A novel hydrogel was prepared via free radical copolymerization ofγ-polyglutamic acid（γ-PGA）and N-isopropyl acrylamide（NIPAAm）.The cross section morphology of the hydrogel was observed by Scanning Electron Microscopy（SEM）.The hydrophilic-hydrophobic properties at different temperature（25、37℃）and the swelling change in various pH ranging from 2.0 to 10.0 were studied.The hydrogels were used as the controlled release carrier for the anticancer drug 5-Fluorouracil（5-FU）,of which the release behavior was studied by the UV spectrophotometric method.Results showed that the drug release rate was lower at neutral pH（7.4）than at acidic and alkaline pH.At 25℃,drug release rate was positively correlated with the content ofγ-PGA,while at 37℃ the result was different.With the noticeable pH-temperature sensitivity and slower drug release rate in weakly alkaline condition,the hydrogels were proposed to be a promising material in the fields of targeted drug delivery.

关 键 词：pH-温度双敏感性 智能水凝胶 控释载体 5-FU 

分 类 号：TB332[一般工业技术—材料科学与工程]