生命分析微流控芯片的多尺度应用:从分子水平到个体水平  

Multiscale Applications of Microfluidic Chip in Life Science:from Molecules to Organisms

作　　者：马超[1] 申少斐 赵磊[1] 王进义[1,2] 

机构地区：[1]西北农林科技大学动物医学院,陕西杨凌712100 [2]西北农林科技大学理学院,陕西杨凌712100

出　　处：《分析测试学报》2015年第3期246-256,共11页Journal of Instrumental Analysis

基　　金：国家自然科学基金资助项目(20775059;20975082;21175107;21375106)

摘　　要：微流控芯片技术是多学科、多领域交叉的新兴分析技术,具有微型化、集成化、高通量、低消耗、高灵敏、分析速度快等特点。如今,微流控芯片技术已发展成为自然科学研究中不可或缺的技术平台,展现出巨大的优势,尤其在生命科学研究中得到了广泛应用。该文概述了近年来微流控芯片技术在分子水平、细胞水平、组织器官水平和生物个体水平等多个尺度上的应用,并对其发展前景进行了展望。Microfluidic technologies, arising from multi-disciplinary intersection, has become an indis- pensable platform in natural science because of its characteristics of miniaturization, integration and high throughput. In this review, the recent applications of microfluidic technologies in life science research were outlined. The applications were divided into four categories according to the scale of the analyzed objects： biomacromolecule analysis, cell-based analysis, organs-on-chips, and studies on small model organisms. And the development prospects of this microfluidic technologies were proposed.

关 键 词：微流控芯片 生物大分子 细胞 器官 生物个体 综述 

分 类 号：O657.1[理学—分析化学] G353.11[理学—化学]