纤维蛋白原和血小板计数等在M3治疗中的临床意义  

Clinical significance of fibrinogen and platelet counting etc. in acute promyelocytic leukemia

作　　者：林朝[1] 李佳真[1] 张苏伟[1] 

机构地区：[1]汕头市中心医院,广东汕头515031

出　　处：《中国校医》2015年第3期236-237,F0003,共3页Chinese Journal of School Doctor

摘　　要：目的探讨纤维蛋白原(FIB)、血小板计数(PLT)、血小板平均体积(MPV)和血小板体积分布宽度(PDW)在急性早幼粒细胞白血病(M3)治疗过程中的临床意义。方法采用贝克曼库尔特ACL TOP700凝血分析仪和贝克曼库尔特LH750血细胞分析仪对50例M3病人治疗前、治疗缓解后的FIB、PLT、MPV和PDW进行测定。结果缓解组FIB较治疗前组显著升高,且治疗前后2组FIB差异有统计学意义(P<0.05);经化学治疗达缓解后PLT比治疗前显著升高,治疗前后2组PLT差异有统计学意义(P<0.01);缓解组MPV和PDW较治疗前组明显降低,治疗前后2组MPV和PDW差异有统计学意义(P<0.05)。结论 FIB、PLT、MPV、PDW是监测急性早幼粒细胞白血病疗效的良好指标。Objective To explore the clinical significance of fibrinogen and platelet counting etc. in acute promyelocytic leukemia. Methods By using Beckman coulter ACL TOP700 blood coagulation analyzer and Beckman coulter LH750 blood corpuscle analyzer, the FIB, PLT, MPV and PDW of 50 patients with acute promyeloeytic leukemia were determined before treatment and after remission. Results FIB of the remission group was increased significantly and there was a significant difference between the remission group and unhealed group （P〈0.05）. After the chemical treatment, PLT of the remission group was increased significantly and there was a significant difference between the two groups above mentioned （P 〈0.01）. MPV and PDW of the remission group were decreased significantly and there were significant differences between the two groups （both P〈0.05）. Conclusion FIB, PLT, MPV and PDW are good indicators in monitoring acute promyelocytic leukemia.

关 键 词：白血病 早幼粒细胞 急性 纤维蛋白原 血小板计数 

分 类 号：R446[医药卫生—诊断学]