IL-4和IL-13基因多态性与维吾尔族儿童哮喘的关联研究进展  

Research Progress of the Relevance of Interleukin 4 and Interleukin 13 Gene Polymorphism with the Uighur Children Asthma

作　　者：魏婷婷[1] 张卫平[2] 

机构地区：[1]新疆医科大学研究生学院,乌鲁木齐830054 [2]新疆医科大学第一附属医院儿科,乌鲁木齐830054

出　　处：《医学综述》2015年第7期1180-1182,共3页Medical Recapitulate

摘　　要：哮喘是常见的呼吸道慢性非特异性炎症,是由遗传和环境因素共同作用的多基因遗传病,白细胞介素(IL)4和IL-13是过敏性炎症的重要介质,在支气管哮喘的发病机制中起重要作用,IL-4和IL-13基因可能是哮喘的候选易患基因之一。研究IL-4和IL-13基因多态性与儿童哮喘的相关性,可揭示其影响哮喘发病的具体途径和环节,确定哮喘易患个体,尽早进行预防和干预;确定遗传因素对药物作用的影响和不同个体对药物反应的差异,为临床合理用药、基因治疗提供理论依据。Asthma is a common chronic respiratory illness.Interleukin 4 and interleukin 13 are important medium of allergic inflammation,playing an important role in the pathogenesis of bronchial asthma.IL-4 and IL-13 genes could be one of the susceptibility gene candidates of asthma.Study of the correlation between IL-4 and IL-13 gene polymorphism and childhood asthma,can reveal the specific ways and links of IL-4 and IL-13 genes affecting asthma pathogenesis,figure out the susceptible individuals to prevent and intervene as early as possible,and determine the genetic influence on drugs and different responses to drugs of different individuals,and provide theoretical basis for rational drug use and gene therapy in clinical.

关 键 词：儿童哮喘 白细胞介素 基因多态性 

分 类 号：R256.12[医药卫生—中医内科学]