山莨菪碱治疗冠状动脉慢血流伴窦性心动过缓的临床观察  

Clinical observation on the treatment of coronary slow flow phenomenon combined sinus bradycardia with anisodamine

作　　者：陈宏[1] 傅涛[1] 程吉[1] 荆忱[1] 

机构地区：[1]空军航空医学研究所附属医院心内科,北京100089

出　　处：《北京医学》2015年第4期350-352,共3页Beijing Medical Journal

摘　　要：目的探讨山莨菪碱对冠状动脉慢血流(CSF)伴窦性心动过缓的疗效。方法选择经冠状动脉造影(CAG)证实冠状动脉未见明显狭窄但存在冠状动脉慢血流伴有窦性心动过缓的患者46例,所有患者随机分为试验组、对照组各23例,对照组给予拜阿司匹林100 mg/d、单硝酸异山梨酯缓释片40 mg/d、阿托伐他汀钙40 mg/d,试验组在此基础上加用山莨菪碱10mg 3/d治疗。观察治疗3个月后两组临床症状及心电图(ECG)的改善、对肝肾功能影响及部分患者冠状动脉血流速度的变化。结果试验组改善临床症状有效率及ECG改善优于对照组74.0%vs.52.2%,78.0%vs.52.0%,P均<0.05,肝肾功能治疗前后无明显改变(P>0.05),复查2组CAG冠脉血流帧计数组间比较,试验组(23.72±2.85),对照组(28.46±3.68)具有明显差异。结论山莨菪碱联合基础治疗对CSF伴窦性心动过缓患者具有较好疗效。Objective To investigate the curative effect of anisodamine on patients with coronary slow flow combined sinus bradycardia. Methods A total of 46 patients with coronary slow flow phenomenon combined sinus bradycardia but normal coronary angiography were included in this study. They were randomly divided into the experimental group（n=23） and control group（n=23）. The control group was treated with aspirin（100 mg/d）, isosorbide mononitrate（40 mg/d）and atorvastatin（40mg/d）. The experimental group was treated with anisodamine added on the routine treatment. Results The experimental group had a better therapeutic effect than the control group（P〈 0.05）. The hepatorenal function had no significant changes than before treatment（P〉 0.05）. The experimental group was significantly lower than that of the control group（23.72 ± 2.85 vs. 28.46 ± 3.68, P〈 0.01）. Conclusion Added on the conventional treatment, anisodamine is a good treatment for CSF combined sinus bradycardia.

关 键 词：冠状动脉慢血流 窦性心动过缓 山莨菪碱 

分 类 号：R543.3[医药卫生—心血管疾病] R541.72[医药卫生—内科学]