PET/CT脑成像新药研究发展趋势及基于PET/CT设备的脑成像新药研发  

R&D Trends of New Drugs for PET/CT Brain Imaging and R&D of New Drugs for Brain Imaging Based on the PET/CT System

作　　者：周克迪 王贺宁[1] 李素莹[1] 孟祥溪 孙红芳[1] 任秋实[1] 

机构地区：[1]北京大学工学院生物医学工程系,北京100081

出　　处：《中国医疗设备》2015年第4期11-14,共4页China Medical Devices

基　　金：国家重大科学仪器专项(2011YQ030114);国家基础研究计划973项目(2011CB707500);国家自然科学基金(11104058);河北省自然科学基金(A2011201155)

摘　　要：脑部分子影像对于脑功能和神经疾病发病机理研究以及早期诊断有重大意义,多巴胺受体系统与人的情绪、爱情、成瘾、奖励机制和一些疾病有重要的联系。本文以新型脑神经多巴胺受体D2/D3显像剂^(18)F-fallypride为例,探讨了^(18)F-fallypride的研究发展和应用趋势,并应用自主研发的AMICRay-Scan 64 PET/CT成像系统对15例健康志愿者进行了临床研究,图像上观测到纹状体和外纹状体的信号清晰,药物分布均匀、对称。此外,脑肿瘤细胞凋亡显像剂^(18)F-ML-10新药可对脑肿瘤的放射性治疗效果进行评估,本文综述了^(18)F-ML-10临床应用的发展,并对10例脑瘤患者接受放射性治疗前后的细胞凋亡情况进行了对比评估,并通过图像对放射性治疗给出评价。Brain molecular imaging plays an important role in investigations on the function of brain and mechanism of neural diseases. The dopaminergic receptor system is closely related with emotion, love, addiction, incentives, many diseases and disorders. Hereby, taking 18F-fallypride as an example of novel dopamine receptor D2/D3 probes visualizing the Dopamine D2/D3 receptors in striatal and extra-striatal areas, this paper reviews the trends of R＆amp;D（Research and Development） and clinical applications of 18F-fallypride, and investigates 18F-fallypride with 15 healthy volunteers’ brain imaging by using the self-innovated AMIC Ray-Scan 64 PET/CT. The result shows a homogeneous and symmetrical distribution of signal in striatal and extra-striatal areas, indicating that the 18F-fallypride, as well as Ray-Scan 64 PET/CT, has demonstrated an excellent performance in dopamine receptor imaging. Additionally, this paper also reviews the progress of clinical uses of 18F-ML-10, a molecular probe to visualize apoptosis. Besides, 10 patients with brain tumorsare investigated by 18F-ML-10-PET/CT imaging pre-and post-radiation with AMIC Ray-Scan 64 PET/CT, in order to evaluate the effect of treatments.

关 键 词：脑成像 分子影像 脑肿瘤 神经 

分 类 号：R197.39[医药卫生—卫生事业管理]