经尿道绿激光汽化术与经尿道电切术治疗膀胱癌的疗效及安全性  

Efficacy and safety of greenlight photoselective laser vaporization versus electrocautery transurethral resection for treating bladder tumors

作　　者：沈弋桢[1] 俞能旺[1] 宋华[1] 付宝琛 张爱民[1] 

机构地区：[1]济南军区总医院泌尿外科,山东济南250001

出　　处：《中国临床研究》2015年第4期426-428,共3页Chinese Journal of Clinical Research

基　　金：国家自然科学基金资助项目(81300624)

摘　　要：目的比较经尿道膀胱肿瘤绿激光汽化术(PVBT)和经尿道膀胱肿瘤电切术(TURBT)治疗膀胱癌的临床疗效及其安全性。方法选取2011年6月至2012年8月收治的膀胱癌患者240例作为研究对象,按治疗方法分为实验组与对照组,每组120例。实验组患者采取PVBT治疗,对照组患者进行TURBT治疗。比较两组患者的手术时间、术中出血量、尿管放置时间、膀胱冲洗时间、住院时间,并发症发生率及两年的累积复发率。结果两组患者的手术时间差异无统计学意义(P>0.05);实验组患者术中出血量、尿管放置时间、膀胱冲洗时间和住院时间均少于对照组,差异均有统计学意义(P<0.05或P<0.01)。实验组患者并发症发生率低于对照组(4.17%vs14.17%,χ2=7.206,P<0.01)。实验组患者两年的累积复发率为7.50%,对照组为18.33%,两组患者两年的累积复发率差异有统计学意义(Log-Rank检验χ2=5.808,P<0.05)。结论 PVBT用于治疗膀胱癌的临床疗效确切,并且安全可靠。Objective To compare the efficacy and safety of greenlight photoselective laser vaporization for bladder tumors（ PVBT） and electrocautery transurethral resection for bladder tumors（ TURBT） for the treatment of bladder cancer. Methods A total of 240 patients with bladder cancer admitted in our hospital between June 2011 and August 2012 were chosen. The patients were divided into two groups according to treatment methods： experimental group and control group（ n =120 each）. The PVBT therapy was given in experimental group,and the TURBT therapy was given in control group. The operation time,blood loss volume in operation,catheter indwelling time,bladder irrigation time,hospital stay time,complications and 2-year cumulative recurrence rate were compared between two groups. Results There was no significant difference in operation time between two groups（ P〉0. 05）. The blood loss volume,catheter indwelling time,bladder irrigation time and hospital stay time in experimental group were all significantly less than those in control group（ all P〈0. 05 or P〈0. 01）. The overall incidence of complications was significantly lower in experimental group than that in control group（ 4. 17% vs 14. 17%,P〈0. 05）. The 2-year cumulative recurrence rate in experimental group was significantly less than that in control group（ 7. 50% vs 18. 33%,P〈0. 05）. Conclusion PVBT has the advantages of definite clinical effect,safety and reliability for the treatment of bladder cancer.

关 键 词：经尿道膀胱肿瘤绿激光汽化术 经尿道膀胱肿瘤电切术 膀胱癌 并发症 复发率 

分 类 号：R737.14[医药卫生—肿瘤]