碳纳米管对镁合金基体上钙磷/壳聚糖膜层释药性能的影响  

The effects of carbon nanotubes on drug release behavior of calcium phosphate / chitosan coating on magnesium alloy substrate

作　　者：张杰[1,2] 迟艳侠[3] 郭晓玲[1] 焦淑清[1] 张向宇[1] 

机构地区：[1]佳木斯大学药学院,黑龙江佳木斯154007 [2]哈尔滨工业大学化工学院,黑龙江哈尔滨154001 [3]佳木斯大学口腔医学院,黑龙江佳木斯154002

出　　处：《黑龙江医药科学》2015年第2期6-7,3,共3页Heilongjiang Medicine and Pharmacy

基　　金：黑龙江省教育厅科学技术研究项目;编号:12541796;黑龙江省卫生厅科学技术研究项目;编号:2013225;佳木斯大学科学技术面上项目;编号:L2012-086

摘　　要：目的:研究碳纳米管对镁合金基体上钙磷/壳聚糖膜层负载的庆大霉素在模拟体液中释放性能的影响。方法:采用浸渍法分别将庆大霉素负载在钙磷/壳聚糖膜层和钙磷/壳聚糖/碳纳米管膜层中,采用紫外分光光度法测定庆大霉素在模拟体液中的释放浓度。结果:镁合金基体上钙磷/壳聚糖膜层负载碳纳米管后,膜层中庆大霉素负载量增加、庆大霉素释放速度降低。结论:碳纳米管有效改善了镁合金基钙磷/壳聚糖骨材料的释药性能。Objective： To study the effect of carbon nanotubes on release behavior of gentamicin loaded in calcium phosphate / chitosan coating on the magnesium alloy substrate in simulated body fluid. Methods： Gentamicin was loaded in the calcium phosphate / chitosan coating and calcium phosphate / chitosan / carbon nanotubes coating by immersion method,respectively. The concentration of gentamicin in simulated body fluid was determined by UV spectrophotometry. Results： Carbon nanotubes were added into the calcium phosphate / chitosan coating on the magnesium alloy substrate. Loading amount of gentamicin in calcium phosphate / chitosan coating was increased,and the release rate of gentamicin was decreased. Conclusion： Carbon nanotubes effectively improved a releasing drug performance of the calcium phosphate / chitosan coating on magnesium alloy substrate.

关 键 词：镁合金 羟基磷灰石 壳聚糖 碳纳米管 庆大霉素 

分 类 号：R318.08[医药卫生—生物医学工程]