老年冠心病患者非体外循环冠状动脉旁路移植术后新发心房颤动的危险因素分析  被引量:15

Atrial fibrillation in the elderly old patients who underwent off-pump coronary artery bypass grafts surgery

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作  者:俞国军[1] 严飞[1] 朱涛[1] 刘正[1] 霍强[1] 

机构地区:[1]新疆医科大学第一附属医院心脏外科一科,乌鲁木齐830054

出  处:《中国心血管杂志》2015年第2期136-140,共5页Chinese Journal of Cardiovascular Medicine

摘  要:目的 探讨老年冠心病患者非体外循环冠状动脉旁路移植术后新发心房颤动的危险因素。方法 回顾性分析159例老年非体外循环冠状动脉旁路移植术后患者资料,根据术后是否新发心房颤动分为两组,分析冠状动脉病变情况、旁路移植血管支数、术后电解质变化、循环血容量变化、抗心律失常药物使用等因素与术后新发心房颤动的相关性。结果 35例患者术后出现心房颤动,发生率22.01%(35/159)。在单因素分析中,心房颤动组患者与非心房颤动组患者比较,年龄[(66.9±5.0)岁比(64.9±3.7)岁,P=0.009]、术前射血分数(42.66%±7.51%比45.94%±8.46%,P=0.039)、术前血氧饱和度(Sp O2,89.67%±6.14%比92.00%±5.34%,P=0.029)、旁路移植血管支数[(3.3±1.4)支比(2.7±1.2)支,P=0.017]、术前3 d脑钠肽(BNP)水平[(850.88±711.55)pg/ml比(523.20±682.57)pg/ml,P=0.014]、术后3 d BNP水平[(2 276.45±1 281.82)pg/ml比(1 444.47±1 163.38)pg/ml,P=0.000]、术后3 d血钾[(3.59±0.24)mmol/L比(4.01±0.62)mmol/L,P=0.000]、术后3 d血钙[(2.31±0.21)mmol/L比(2.23±0.07)mmol/L,P=0.000]、住院天数[(21.5±5.4)d比(19.4±4.8)d,P=0.026]等指标差异均有统计学意义。Logistic回归分析显示,年龄(OR:0.87,95%CI:0.776~0.976)、合并心脏瓣膜病(OR:0.149,95%CI:0.034~0.658)、术前Sp O2(OR:1.092,95%CI:1.012~1.117)、旁路移植血管支数(OR:0.543,95%CI:0.349~0.845)、术后3 d BNP水平(OR:1.000,95%CI:0.999~1.000)、术后3 d血钾(OR:3.842,95%CI:1.227~12.029)、术后3 d血钙(OR:0.007,95%CI:0.000~0.520)与术后新发心房颤动具有显著相关性(均为P〈0.05)。结论 年龄〉65岁、合并心脏瓣膜病、术前Sp O2〈90%、旁路移植血管支数〉3支、围术期电解质紊乱是老年非体外循环冠状动脉旁路移植术后新发心房颤动的危险因素。Objective To examine the incidence and risk factors associated with new onset atrial fibrillation (AF) in the elderly coronary heart disease patients who underwent off-pump coronary artery bypass (OPCAB) surgery. Methods From April 2012 to April 2014, 159 elderly patients received OPCAB in our hospital. The patients were divided into AF group and non-AF group. Statistic analyses were used to screen risk factors of new onset AF after OPCAB. Results The incidence of AF after OPCAB is 22. 01%. Univariate analysis demonstrated that patients in AF group compared with those in non-AF group were more likely advanced age [(66. 9 ± 5. 0) years vs. (64. 9 ± 3. 7) years, P = 0. 009], preoperative SpO2 level (89. 67% ± 6. 14% vs. 92. 00% ± 5. 34% , P = 0. 029), preoperative EF (42. 66% ± 7. 51% vs. 45. 94%± 8. 46% , P = 0. 039), the numbers of vascular grafting [(3. 3 ± 1. 4)b vs. (2. 7 ± 1. 2)b, P = 0. 017], postoperative 3 days BNP level [(2 276. 45 ± 1 281. 82) pg/ ml vs. (1 444. 47 ± 1 163. 38) pg/ ml, P =0. 000], postoperative 3 days blood potassium level [(3. 59 ± 0. 24)mmol/ L vs. (4. 01 ± 0. 62)mmol/ L, P= 0. 000], postoperative 3 days serum calcium level [(2. 31 ± 0. 21)mmol/ L vs. (2. 23 ± 0. 07)mmol/ L, P = 0. 000], preoperative 3 days BNP level [(850. 88 ± 711. 55)pg/ ml vs. (523. 20 ± 682. 57)pg/ ml, P= 0. 014], hospitalization days [(21. 5 ± 5. 4) d vs. (19. 4 ± 4. 8) d, P = 0. 026]. Multivariate Logistic regression analyzes showed that age ( OR: 0. 87, 95% CI: 0. 776 - 0. 976), suffering from heart valve disease (OR: 0. 149, 95% CI: 0. 034 - 0. 658), preoperative SpO2 level (OR: 1. 092, 95% CI: 1. 012 -1. 117), the numbers of vascular grafting (OR: 0. 543, 95% CI: 0. 349 - 0. 845), postoperative 3 days BNP level (OR: 1. 000, 95% CI: 0. 999 - 1. 000), postoperative 3 days blood potassium level ( OR:3. 842, 95% CI: 1. 227 - 12. 029), postoperative 3 days serum calcium l

关 键 词:心房颤动 冠状动脉疾病 冠状动脉旁路移植术 非体外循环 老年人 危险因素 

分 类 号:R654.2[医药卫生—外科学]

 

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