地处平原的高原世居藏族人群血尿酸与血红蛋白水平的相关性研究  

Relationship Between Serum Uric Acid and Hemoglobin Levels in Native Tibetans in Plain Area

作　　者：邬云红[1] 刘琳[2] 潘柏莉 向省平 陈艳[3] 李晓萍[1] 

机构地区：[1]西藏自治区人民政府驻成都办事处医院内分泌代谢科,四川省成都市610044 [2]西藏自治区人民政府驻成都办事处医院检验科,四川省成都市610044 [3]西藏自治区人民政府驻成都办事处医院内检验科,四川省成都市610044

出　　处：《中国全科医学》2015年第7期792-796,共5页Chinese General Practice

摘　　要：目的探讨世居高原藏族人群在平原地区血尿酸(SUA)水平与血红蛋白(HGB)的关系。方法采用横断面调查的方法,选取2013年1—5月在西藏自治区人民政府驻成都办事处医院门诊进行健康体检的世居西藏高原藏族人群1 722人,进行SUA、血肌酐(SCr)、血脂、肝功及血常规检查。其中男957例,女765例;平均年龄为(46±14)岁。将男性SUA>420μmol/L,女性SUA>357μmol/L界定为高尿酸血症(HUA),分析HUA患病率、SUA水平及其与HGB的关系。结果 (1)藏族健康体检人群HUA患病率为22.82%(393/1 722),其中男性为30.30%(290/957),女性为13.46%(103/765);二者比较差异有统计学意义(χ2=68.44,P<0.001)。(2)在排除肝功、血脂、估计肾小球滤过率(e GFR)等因素影响下,HGB与SUA仍呈正相关(r=0.224,P<0.001)。(3)高原红细胞增多症患者HUA患病率为13/19,高于无高原红细胞增多者22.31%(380/1 703),差异有统计学意义(χ2=22.68,P<0.001)。(4)不同性别多因素Logistic回归分析显示,e GFR增加是HUA保护因素,而HGB的增高是HUA发生的独立危险因素。结论世居高原藏族人群下至平原在解除低氧刺激后,HGB与SUA水平呈正相关,HGB也是HUA的独立危险因素,提示高原藏族人群HUA患病率高的原因之一可能与低氧刺激的红细胞增生相关。Objective To explore the relationship between serum uric acid and hemoglobin levels in native Tibetans who come to plain Area. Methods In this cross- sectional study,we analysed the selected data from 1 722 native Tibetans who received health examination in Chengban Branch of West China Hospital from January to May 2013. The data from SUA,serum creatinine,blood lipids,liver function and blood routine examinations were included. Of the 1 722 Tibetans,957 were male and765 were female,with a mean age of（ 46 ± 14）. SUA 420 μmol / L in males and SUA 357 μmol / L in females were defined as hyperuricemia. The prevalence rate of HUA and the association between SUA and HGB levels were evaluated. Results（ 1）The prevalence rate of HUA was 22. 82%（ 393 /1 722）,males 30. 30%（ 290 /957） and females 13. 46%（ 103 /765）; there is a statistical significance in the data discrepancy（ χ^2= 68. 44, P〈 0. 001）.（ 2） After excluding the influence of liver function,blood lipids and e GFR,positive correlation still existed between HGB and SUA（ r = 0. 224,P〈 0. 001）.（ 3） The prevalence rate of HUA in people with high altitude polycythemia was significantly higher than those without it 〔13 /19 vs. 22. 31%（ 380 /1 703）,P〈 0. 001〕.（ 4） The binary logistic regression analysis based on different genders showed that the increase of e GFR was a protective factor for HUA, while the increase of HGB was an independent risk factor for HUA. Conclusion HGB level is positively correlated with SUA level and is an independent risk factor for HUA in native Tibetans when they come to plain area without hypoxia stimulation. The high prevalence of HUA in native Tibetans might be partially due to polycythemia induced by hypoxia.

关 键 词：藏族 尿酸 血红蛋白测定 相关性分析 

分 类 号：R446.112.4[医药卫生—诊断学]