复合皮瓣修复兔模型腿和足骨缺损皮肤创伤的研究  

Experimental study on composite flap for repair of bone defect of rabbit model of leg and foot skin trauma

作　　者：王志斌[1] 王黎敏[2] 张慧鹏[1] 

机构地区：[1] 长治医学院附属和济医院急诊外科,山西046000 [2] 长治医学院机能综合实验室

出　　处：《中华实验外科杂志》2015年第4期861-863,共3页Chinese Journal of Experimental Surgery

摘　　要：目的 探讨复合皮瓣修复兔模型小腿皮肤创伤缺损的应用效果.方法 选择新西兰大白兔36只,通过装置模拟重物砸伤、挤压伤等,建立大白兔胫骨或跖骨骨折和小腿及足部软组织缺损的动物模型,成功27只,并采用异体骨移植、带胫骨骨膜的复合皮瓣修复胫骨骨折和皮肤缺损,其中串联带隐神经和骨膜的胫后动脉复合组织瓣修复前足2只.结果 27只模型的复合皮瓣全部成活,3例皮瓣远端表层部分坏死,经换药创面愈合.术后X线复查,移植异体骨对位好,恢复了兔的足弓.本组随访3～9个月,平均5个月,植入的异体骨骨性愈合,未见明显吸收、感染和排斥反应等并发症.足外形美观,可正常行走.结论 应用异体骨移植,取材方便,可恢复足弓.采用带骨膜的复合胫前动脉逆行皮瓣,不影响患足的供血,加速骨的愈合.缩短疗程,操作简单,外形好,可恢复大白兔模型足的行走功能.Objective To investigate the effect of application of composite flap for repairing leg skin defect in rabbit traumatic model.Methods Thirty-six New Zealand rabbits by device simulation,bruise,crush injury,animal model rabbit tibia orfracture of metatarsal bone and soft tissue defects of leg and foot,27 cases were successful,and the use of allogeneic bone transplantation,with tibial periosteumcomposite flap for repair of tibial fracture and skin defect,wherein the series with hidden nerve and periosteum of the posterior tibial artery composite tissue flap to repair forefoot in 2 cases.Results The composite skin flaps in 27 cases survivedand 3 cases of the model,the distal end of the flap surface partial necrosis,healed by dressing.Postoperative X-ray review,allograft bone alignment,restorefoot transverse and longitudinal arch.The patients were followed up for 3 months to 9 months,implant bone allograft bone healing,no obvious absorption,infection and rejection and other complications.The foot of beautiful shape,can be a normal walking.Conclusion The application of allogeneic bone transplantation,convenient,can restore the arch.Used with periosteum composite reverse anterior tibial artery flap,does not affect the patient enough blood supply,accelerate the healing of bone.Shorten the course of treatment,simple operation,good appearance and walking function can be restored in rabbit model of foot.

关 键 词：骨 足 皮瓣 创伤缺损 

分 类 号：R658.3[医药卫生—外科学]