河南省HIV新报告感染者和长期感染者的病程进展调查  

Research of HIV progression between newly reported and chronically infected patients in Henan

作　　者：薛秀娟[1] 刘佳[1] 田随安[1] 刘春华[1] 孙国清[1] 孙定勇[1] 朱谦[1] 王哲[1] 

机构地区：[1]河南省疾病预防控制中心,河南郑州450016

出　　处：《现代预防医学》2015年第8期1495-1497,共3页Modern Preventive Medicine

基　　金：河南省医学科技攻关计划省部共建项目(2011010016);河南省疾病预防控制中心科研基金课题;河南省防治艾滋病规模化现场流行病学和干预研究(2012ZX10004905)

摘　　要：目的分析河南省不同病程的HIV感染者同时段检测指标变化特征。方法回顾性研究58例新报告感染者和68例长期感染者,分析2组感染者2011年至2013年期间CD4+T淋巴细胞、病毒载量(Viral Load,VL)变化情况。采用In-house方法,探讨2组感染者原发耐药状况。结果新报告感染者的CD4+T淋巴细胞2年内从658(520,829)个/μl下降至394(274,529)个/μl,长期感染者从481(292,626)个/μl降低至385(247,520)个/μl,前者变化差异有统计学意义(Z=36.64,P<0.05)。组内比较2组感染者VL差异无统计学意义(Z=0.45,P>0.05;Z=0.20,P>0.05),组间比较显示长期感染者VL高于新报告感染者,差异有统计学意义(Z=2.38,P<0.05;Z=3.16,P<0.05)。新报告感染者和长期感染者耐药发生率分别为5.17%(3/58)、11.76%(8/68)。结论新报告感染者病程进展快于长期感染者,应加强全省未治疗感染者的跟踪随访和抗病毒治疗前的耐药检测。Objective The aim of this study was to analyze the variation of different courses of HIV infection during the same period in Henan. Methods Fifty-eight cases of newly reported and 68 cases of chronically infected persons were enrolled in retrospective study. The CD4＋T lymphocytes and VL changes were analyzed from 2011 to 2013. In-house methodologies were used to explore primary drug resistance for the two groups. Results Within two years, The CD4^＋T lymphocytes of newly reported patients decreased from 658（520,829） to 394（274,529）, and chronically infected patients reduced from 481（292,626） to 385（247,520）, with statistically significant of the former difference（Z=36.64, P〈0.05）. When comparing the VL within the two groups, there was no significant difference（Z=0.45, P〉0.05; Z=0.20, P〉0.05）. The VL of chronically infected patients were higher than the newly reported patients, the differences of VL between the two groups were statistically significant（Z=2.38, P〈0.05; Z=3.16, P〈0.05）. Rate of drug resistance between newly reported and chronically infected patients were 5.17%（3/58） and 11.76%（8/68）. Conclusion The progression of HIV infection in newly reported patients were faster than the chronically infected patients. It is necessary to strengthen the follow-up tracking and drug resistance detection of untreated infected person in whole province.

关 键 词：新报告感染者 长期感染者 原发耐药 

分 类 号：R183[医药卫生—流行病学]