评价中西医结合疗法对慢性乙型肝炎ALT、HBeAg和HBV-DNA的影响  

Effect of the combination of traditional Chinese and western medicine therapy on ALT, HBeAg and HBV-DNA of chronic hepatitis b patients

作　　者：侯著丰 余世敏 胡东辉 

机构地区：[1]湖北省建始县中医院,湖北恩施445300 [2]湖北省中山医院肝病科,湖北武汉430033

出　　处：《现代预防医学》2015年第8期1535-1536,F0003,共3页Modern Preventive Medicine

摘　　要：目的评价中西医结合疗法对慢性乙型肝炎ALT,HBe Ag和HBV-DNA的影响。方法选择2010年4月-2013年6月某院收治的慢性乙型肝炎患者88例作为观察对象。将患者随机分为观察组及对照组,观察组及对照组患者均采用拉米夫定进行抗病毒治疗,观察组在此基础上采用中药进行疏肝解郁、调养肝脾治疗,同时根据患者症状加用不同方剂。比较2组患者治疗24周时、治疗48周时、72周时ALT正常率、HBe Ag转阴率、HBV-DNA转阴率,并评价治疗的安全性。结果观察组与对照组ALT正常率在24周时无差异,但48周及72周时差异有统计学意义,观察组的ALT正常率高于对照组(P<0.05);2组间HBe Ag转阴率在各观察时点间均无统计学差异(P>0.05);2组HBV-DNA转阴率在24周时无差异,但48周及72周时差异具有统计学意义,观察组的HBV-DNA转阴率高于对照组(P<0.05)。治疗过程中2组患者均未出现与药物有关的不良反应,2组患者生命体征、肾功、尿常规、心电图监测结果也较为平稳,未发现患者出现异常改变。结论中西医结合疗法能够提高慢性乙型肝炎ALT的正常率和HBe Ag以及HBV-DNA的转阴率。Objective This work aimed to evaluate the effect of the combination of traditional Chinese medicine therapy with and western medicine on ALT, HBe Ag and HBV-DNA of hepatitis B patients. Methods 88 patients with chronic hepatitis B in our hospital during April 2010- June 2013 were chosen as subjects. Patients were randomly divided into an observation group and a control group. Both groups were treated with lamivudine antiviral therapy. On top of that, the observation group were further treated using traditional Chinese medicine（TCM） to relieve depression of liver and spleen. according to the symptoms of patients. The two groups were compared at 24 w, 48 w and 72 w for the level of ALT, HBe Ag, and HBV- DNA, so as to evaluate the safety of the treatment. Results No difference was observed on the rate of normal ALT between the observation group and the control group at 24 w. However, at 48 w and 72 w the rate of normal ALT in the observation group was significantly higher than the control group（P〈0.05）. No difference in the rate of HBe Ag turning to negative was observed between the two groups（P〉0.05）. At 24 w no difference in the rate of HBV-DNA turning negative was observed between the two groups, at 48 w and 72 w the rate of the observation group was higher than that of the control group（P〈0.05）. During the process of treatment, both groups showed no drug related adverse reaction, and. the vital signs of renal function, urine routine indexes and electrocardiogram monitoring results were relatively stable in both groups. Conclusion Combining traditional Chinese medicine therapy with western medicine can significantly improve the efficacy of the treatment against chronic hepatitis B.

关 键 词：慢性乙型肝炎 ALT HBEAG HBV-DNA 

分 类 号：R512.62[医药卫生—内科学]