茚虫威对映体对斑马鱼毒性的手性选择性试验  

Chiral Selective Toxicity Effect of Indoxacarb Enantiomers on Zebrafish

作　　者：张钰萍[1] 张万敏 柳敏[1] 卢平[1] 陈泠竹[1] 曾松[1] 

机构地区：[1]贵州大学绿色农药与农业生物工程国家重点实验室培育基地、教育部绿色农药与生物工程重点实验室、精细化工研究开发中心,贵阳550025 [2]化学与化工学院,贵阳550025

出　　处：《农药》2015年第4期278-281,共4页Agrochemicals

基　　金：国家自然科学基金项目(21367007);贵州省科技厅重大专项(黔科合重大专项字[2013]6024号)

摘　　要：[目的]比较茚虫威富集体(2.33S:1R)、光学纯S体及光学纯R体对斑马鱼的的急性毒性差异。[方法]通过制备分离得到茚虫威纯R体和纯S体,采用半静态法,研究茚虫威对非靶标生物斑马鱼的急性毒性。[结果]3个化合物对斑马鱼急性毒性从大到小排列为光学纯茚虫威S体>茚虫威富集体(2.33S:1R>光学纯茚虫威R体。[结论]现阶段市场上茚虫威纯S体和富集体产品共存,2者对斑马鱼的毒性都较大,应该避免其在养鱼区附近使用。[Aims] The acute toxicity effects of individual enantiomers of indoxacarb on zebrafish were studied. [Methods] The two enantiomers of indoxaearb were prepared by separation in laboratory, and the acute toxicity to zebrafish was determined by semi-static method. [Results] The order ofthe toxicity to zebrafish for three compounds was optical pure S-indoxacarb 〉 indoxacarb concentrate（2.33S： 1R） 〉 optical pure R-indoxacarb. [Conclusions] Enriched formulation of S-isomer and pure S-isomer are both sold in Chinese markets, however, their application in aquaculture regions should be prohibited due to their toxicity to zebrafish.

关 键 词：茚虫威 对映体 斑马鱼 急性毒性 

分 类 号：TQ450.261[化学工程—农药化工]