鲍氏不动杆菌临床分布特征与耐药变迁分析  

Analysis on clinical distribution of Acinetobacter baumanniiand drug resistance

作　　者：闵利[1] 温汉春[1] 陈一强[1] 黄宏[1] 梁宏洁[1] 李萌[1] 晏奎[1] 

机构地区：[1]广西医科大学第一附属医院急诊科,广西南宁530021

出　　处：《中华医院感染学杂志》2015年第8期1690-1692,共3页Chinese Journal of Nosocomiology

基　　金：广西教育厅基金资助项目(200710MS156)

摘　　要：目的分析鲍氏不动杆菌的临床分布特征及耐药变迁,为临床抗感染用药提供参考。方法收集医院2012年6月-2013年5月住院患者所送标本分离培养出的558株鲍氏不动杆菌进行药敏试验,统计其药敏结果及临床相关资料,用SPSS16.0软件统计分析菌株对抗菌药物的耐药率及不同科室的耐药特点,分析耐药趋势。结果 558株鲍氏不动杆菌标本来源以痰液为主,共391株占70.07%;对常用抗菌药物敏感率较高的前3位分别为:阿米卡星58.6%、头孢哌酮/舒巴坦40.8%、亚胺培南38.7%;除头孢哌酮/舒巴坦外,对其余药物耐药率均较2011年下降。结论鲍氏不动杆菌感染以呼吸道感染为主,加强医院感染管理可有效降低耐药率;ICU的耐药率明显高于普通病房。OBJECTIVE To analyze the clinical distribution features and drug resistance and changing tendency of Acinetobacter baumannii（ABA）in order to offer reference for the clinical anti-infection therapy.METHODS Drug susceptibility tests were conducted on totally 558 isolated and cultured ABA strains from specimens collected from inpatients treated during Jun.2012 to May 2013.Susceptibility results and clinical relevant data were summarized and the software SPSS16.0was used for the statistical analysis of the resistant rate of strains to antibacterial agents and the resistance characteristics in different departments to reveal the resistant trend.RESULTS Sputum took the highest proportion of specimens（391strains,72.04%）.Antibacterials with the susceptibility rates ranking the first three were amikacin（58.6%）,cefoperazone/sulbactam（40.8%）,and imipenem（38.7%）.The resistance rates to antibacterials,except cefoperazone/sulbactam,were lower than that in 2011.CONCLUSION A.baumannii mainly causes respiratory infections.Enhancement of the management of hospital infections can reduce resistance rates effectively.The resistance rate in ICU is obviously higher than in general wards.

关 键 词：鲍氏不动杆菌 多药耐药 药敏分析 

分 类 号：R378[医药卫生—病原生物学]