外阴阴道假丝酵母菌属感染分布与耐药性分析  

Analysis of distribution and drug resistance of Candida in patients with vulvovaginal infections

作　　者：吴海[1] 何佳[1] 鄢利梅[1] 杨学荣[1] 

机构地区：[1]遂宁市中心医院妇产科,四川遂宁629000

出　　处：《中华医院感染学杂志》2015年第8期1704-1706,共3页Chinese Journal of Nosocomiology

基　　金：四川省卫生厅科研基金资助项目(080735)

摘　　要：目的探讨外阴阴道假丝酵母菌感染临床特点以及对常用抗菌药物的耐药性,为临床诊断和及时治疗提供依据。方法检测分析医院2011年8月-2013年8月15 000例女性患者外阴阴道送检分泌物标本分离出的假丝酵母菌属,鉴定所得标本的菌种属性,分析耐药性,数据采用SPSS 14.0软件进行统计分析。结果 15 000份标本进行检测,检测出1 980份有假丝酵母菌属的感染,检出率为13.2%,其中以白色假丝酵母菌为主,共1415株占71.5%;耐药率最高的是伊曲康唑,耐药率达28.88%,氟康唑为10.44%、伏立康唑为11.52%,但对于两性霉素B以及氟胞嘧啶几乎全部敏感。结论女性外阴阴道的假丝酵母菌属感染以白色假丝酵母菌感染为主,且不同药物有不同的耐药程度,因此要加强临床对于假丝酵母菌属的检测,从而更好的指导临床准确及时的治疗。OBJECTIVE To discuss the clinical features of vulvovaginal infections of Candidaand drug resistance to common antibiotics,so as to provide the basis for clinical diagnosis and timely treatment.METHODS The Candidaisolated from secretion samples of 15 000 cases of patients from Aug.2011 to Aug.2013 were detected.The property of the strains was identified and the drug resistance was analyzed.All data were statistically analyzed by SPSS 14.0software.RESULTS Totally 15 000 samples were detected by bacteriological testing,and 1980 samples were found to be infected by Candida,with the detection rate of 13.2%.Among them,Candida albicans with 1415 strains dominated by 71.5%.The drug resistant rate of Candidato itraconazole was the highest of 28.88%and to fluconazole,it was 10.44%,to voriconazole 11.52%.almost all were sensitive to Amphotericin B and 5-flucytosine.CONCLUSION C.albicans are the main bacteria infected by female vulva and vagina.And different drugs have different levels of drug resistance,so we need to strengthen the clinical test for Candidato better guide clinical accurate and timely treatment.

关 键 词：外阴阴道 假丝酵母菌属 感染 耐药性 

分 类 号：R379[医药卫生—病原生物学]