预防性应用抗菌药物对血管介入治疗患者术后感染的影响研究  

Clinical effect of prophylactic treatment of antimicrobial drugs on postoperative infection in patients undergoing vascular intervention

作　　者：周健[1] 郭英辉[2] 陈金金[2] 杨斌[1] 

机构地区：[1]杭州市第一人民医院放射科,浙江杭州310006 [2]杭州市第一人民医院消化内科,浙江杭州310006

出　　处：《中华医院感染学杂志》2015年第8期1758-1760,共3页Chinese Journal of Nosocomiology

基　　金：浙江省卫生厅重点基金资助项目(ZW-2010B-019)

摘　　要：目的探讨血管介入治疗患者预防性应用抗菌药物对其术后感染的影响,为临床治疗提供指导。方法选取2011年4月-2013年12月收治行介入治疗的患者280例,随机分为两组,对照组136例、观察组144例,对照组患者在介入治疗围手术期不预防性应用抗菌药物,观察组患者在术前给予头孢唑林预防性治疗,对两组患者体温升高、中性粒细胞增加、C-反应蛋白升高及其切口感染、介入靶器官感染进行调查统计,采用SPSS13.0软件进行统计分析。结果观察组术后发热、中性粒细胞增加分别为40例占29.41%、8例占5.88%,对照组分别为46例占31.94%、10例占6.94%,两组患者均无C-反应蛋白升高;观察组患者住院时间为(10.26±0.81)d,对照组为(7.50±0.72)d,上述比较两组差异均无统计学意义。结论预防性应用抗菌药物并不会降低血管介入治疗术后的感染概率,反而会增加患者费用,因此认为血管介入治疗无需预防性应用抗菌药物。OBJECTIVE To investigate the prophylactic antimicrobial effect on postoperative infection in patients receiving vascular intervention so as to provide guidance for clinical treatment.METHODS Totally 280 patients receiving interventional therapy in Apr.2011-Dec.2013 were enrolled and randomly divided into two groups,the control group（n=136）and the observation group（n=144）.The control group did not take perioperative antimicrobial prophylaxis for interventional treatment,while the observation group was given preoperative prophylactic cefazolin intravenously.The two groups of patients were investigated for increased body temperature,increased neutrophils,elevated C-reactive protein,incision infection and target organ infections.The software SPSS 13.0was used for statistical analysis.RESULTS Postoperative fever,increased neutrophils occurred in 40 cases accounting for 29.41%,and 8cases（5.88%）respectively in the observation groups,and 46cases（31.94%）,10cases（6.94%）in the control group.Neither groups had increased C reactive protein.The hospitalization time was（10.26±0.81）d in the observation group,and（7.50±0.72）d in the control group.The above comparison between the two groups was not significant.CONCLUSIONProphylactic antimicrobial drugs do not reduce the probability of postoperative infection in vascular interventional treatment,which,on the contrary,will increase patients＇ costs.Therefore,it is concluded that prophylactic antibiotics are unnecessary for vascular interventional treatment.

关 键 词：抗菌药物 血管介入治疗 感染 

分 类 号：R978.1[医药卫生—药品]