α-四(对磺酸钠苯氧基)酞菁锌(钴,镍)光敏剂的光动力性质研究  

Research of photodynamic properties of α-PhSPcZn(Co,Ni) photosensitizer

作　　者：陈伟[1] 李婷婷[1] 夏春辉[2] 李涛[2] 周中林[1] 邸凯[1] 

机构地区：[1]齐齐哈尔大学化学与化学工程学院,黑龙江齐齐哈尔161006 [2]齐齐哈尔医学院,黑龙江齐齐哈尔161042

出　　处：《分子科学学报》2015年第2期150-154,共5页Journal of Molecular Science

基　　金：黑龙江省自然科学基金重点项目(ZD201318);黑龙江省教育厅科学技术研究项目(12531776)

摘　　要：采用UV-Vis光谱、红外吸收光谱、CHN元素分析及激光解析飞行时间质谱对α-四（对磺酸钠苯氧基）酞菁锌（钴,镍）[α-PhSPcZn（Co,Ni）]进行表征.在光诱导条件下,采用四甲基偶氮唑蓝比色法（MTT法）,考察了光敏剂的中心原子、浓度和光照时间等条件下对癌细胞的抑制作用.结果显示,光照15min、浓度为0~100mg·L-1范围内时,α-PhSPcZn的抑瘤率高于α-PhSPcCo和α-PhSPcNi.抑瘤率均随光照时间和配合物浓度的增加而升高,α-PhSPcZn的抑制率可达54%,其IC50值为75mg·L-1.α-tetra（p-sodium sulfonicphenoxy）phthalocyanine Zn（Co,Ni）was characterized by using UV-Vis absorption spectra,IR spectra,elemental analysis and TOF-MS.The influences of phthalocyanine central atom and concentration and the illumination on SGC-7901 cancer cells inhibition were studied by MTT colorimetric assay under condition of photoinduce.The results showed that the experiment at light for 15 minutes and concentration in the range of 100μg·mL-1,theα-PhSPcZn inhibition of tumor efficiency higher thanα-PhSPcCo andα-PhSPcNi.The cancer inhibition will improve along with the increase of both illumination duration and complex concentration.α-PhSPcZn complex can reach 67% under the concentration of 100 mg·L-1 on SGC-7901 cells.Its IC50 numerical value was 75mg·L-1.

关 键 词：α-四(对磺酸钠苯氧基)酞菁锌(钴 镍) 光敏剂 光动力疗法 抑瘤率 胃癌SGC-7901细胞 

分 类 号：O644[理学—物理化学]