柴胡皂苷d药理与毒理作用研究进展  

Research Developmenton Pharmacological Effects and Toxicity of Saikosaponin- d

作　　者：李晓宇[1] 窦立雯 孙佳惠 孙蓉[1] 

机构地区：[1]山东省中医药研究院,山东济南250014 [2]山东中医药大学,山东济南250355 [3]山东大学,山东济南250012

出　　处：《中国药物警戒》2015年第4期207-210,共4页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金面上项目(81374059);山东省自主创新和成果转化项目(2014ZZCX02104);山东省自然基金重点项目(2011ZRB14333)

摘　　要：目的对柴胡皂苷d近10年有关药理及毒理的研究内容进行综述。方法查阅国内外研究文献,对柴胡属植物中有效成分柴胡皂苷d的药理研究和毒性研究进行归纳、总结。结果柴胡皂苷d具有抗肿瘤、抗癌、保肝、雌激素样等药理作用,对治疗肾病也有一定的疗效。毒理学研究表明,该成分的急性毒性很强,且具有溶血作用和很强的体外肝毒性,对肝脏有损伤。结论柴胡皂苷d体外诱导细胞膜通透性改变,从而导致细胞损伤甚至是坏死;其毒性靶器官可能为肝脏,肝损伤机制可能与同多途径的氧化应激损伤有关。Objective To review the researches of pharmacological effects and toxicity of saikosaponin-d, which is the chemical components of Bupleurum. Methods References in the last decades at home and abroad about the pharmacological effects and toxicity of saikosaponin-d were collated, analyzed and summarized, which was the main effective components of Bupleurum. Results Saikosaponin-d had the pharmacological effects of anti-tumor, liver protection, potential estrogen-like effect and nephropathy protection. Toxicology showed that saikosaponin-d had high toxicity, such as haemolytic effect, high hepatotoxicity in vitro. Conclusion Saikosaponin-d can induce the change of cell membrane penetrability, which lead to cell damage or necrocytosis. The toxic target organ may be liver and liver, injury may be connected with multiple pathways oxidative stress damage.

关 键 词：柴胡 柴胡皂苷 d 肝毒性 药效学 

分 类 号：R917[医药卫生—药物分析学] R286[医药卫生—药学]