干细胞再生和修复心肌的现状与挑战  

Stem Cell in Cardiac Repair and Regeneration: Current Status and Challenge

作　　者：冯宇亮[1,2,3] 余细勇[1,2,3] 

机构地区：[1]广东省心血管病研究所 [2]广东省人民医院广东省医学科学院 [3]华南理工大学医学院,广州510080

出　　处：《生理科学进展》2015年第2期87-93,共7页Progress in Physiological Sciences

基　　金：国家自然科学基金重点项目(81120108003;81330007);国家973计划课题(2012CB526602)资助课题

摘　　要：心肌梗死的发病率日益增加,但目前标准疗法的效果不尽如人意。因此,人们不断探索新的治疗手段。近年来,干细胞被认为是再生和修复心肌的重要来源之一,已有多种类型的干细胞被证明具有向心肌分化的能力。目前,全球范围内已有数千名心梗患者接受自体干细胞治疗,但结果喜忧参半。本文将就当前干细胞在心肌再生和修复的研究进展进行综述并提出尚待解决的重要问题。In the context of a growing pandemic of myocardial infarction （MI）,the current standard therapies cannot provide an ideal outcome for the patients.Hence,novel approaches are being explored to identify curative treatment.In recent years,stem cell has been regarded as a critical source for cardiac regeneration,and several types of stem cells have been demonstrated with cardiogenic capacity.To date, thousands of patients with MI have received autologous stem cells therapy,but the benefits were modest. In this review,we summarize the recent findings of stem cells therapy in cardiac repair and regeneration, and propose the key unsolved hurdles in this field.

关 键 词：干细胞 心肌梗死 再生 修复 

分 类 号：R541[医药卫生—心血管疾病]