小剂量辛伐他汀联合厄贝沙坦对血脂正常的轻中度高血压者颈动脉内-中膜厚度的影响  

Effect of combined treatment of small doses simvastatin and irbesartan on carotid intima-media thickness in patients with mild-to-moderate hypertension and normal serum lipid level

作　　者：汤峥丽[1] 张晓一[1] 张晓天[1] 

机构地区：[1]上海中医药大学附属曙光医院,上海201203

出　　处：《上海预防医学》2015年第4期222-225,共4页Shanghai Journal of Preventive Medicine

摘　　要：[目的]观察小剂量辛伐他汀联合厄贝沙坦对血脂正常的轻、中度高血压患者颈动脉内-中膜厚度（IMT）的影响,探讨其降压、降脂以外的血管保护作用。[方法]124例血脂正常的1~2级原发性高血压伴有不同程度颈动脉IMT增厚患者随机分为2组,观察组（辛伐他汀联合厄贝沙坦）64例,对照组（厄贝沙坦）60例,3个月为1个疗程,共2个疗程,比较两组治疗前后IMT、血压及血脂水平变化。[结果]治疗6个月后,两组收缩压、舒张压、IMT较治疗前均有明显降低,其中观察组IMT降低最明显（P〈0.05）。观察组血总胆固醇、低密度脂蛋白胆固醇下降,高密度脂蛋白胆固醇升高,差异均有统计学意义（P〈0.01）。[结论]小剂量辛伐他汀联合厄贝沙坦在有效降压、调脂的基础上,对血脂正常的轻、中度高血压患者的颈动脉IMT增加有良好的逆转作用,可以改善颈动脉硬化程度,延缓动脉粥样硬化进展。[Objective] To observe the effect of combined treatment of small doses simvastatin and irbesartan for carotid intima-media thickness（ IMT） in patients with mild-to-moderate hypertension and normal serum lipid level. [Methods] A total of 124 patients with mild-to-moderate hypertension and normal serum lipid level were randomly divided into the observation group（ simvastatin combined with irbesartan） of 64 cases and the irbesartan group of 60 cases. Three months were as a course of treatment,and each patient in both groups received two courses; IMT,blood pressure and blood lipids were compared in the two groups before and after treatment. [Results] After treatment of six months,systolic and diastolic blood pressure,IMT in both groups were significantly decreased,and IMT in the observation group was lower than that in the control group（ all P〈 0. 05）. In observation group,TC and LDL-C levels were significantly decreased,and HDL-C level was significantly increased（ all P〈0. 01）. [Conclusion] Besides lowering blood pressure and blood lipids levels,combined treatment of small doses simvastatin and irbesartan has good reverse effect on increased IMT and improves carotid atherosclerosis in patients with mild-tomoderate hypertension and normal serum lipid level.

关 键 词：高血压 血脂 颈动脉内-中膜厚度(IMT) 辛伐他汀 厄贝沙坦 

分 类 号：R544.11[医药卫生—心血管疾病]