丹皮酚脂质体凝胶剂的透皮作用机制考察  

Transdermal Diffusion Action Mechanism of Paeonol Liposome Gel

作　　者：白发丽[1] 曹芬[2] 

机构地区：[1]广西壮族自治区广西柳州市中医院,广西柳州545001 [2]广西药用植物园,广西南宁530023

出　　处：《中国药业》2015年第8期23-25,共3页China Pharmaceuticals

摘　　要：目的研究丹皮酚脂质体凝胶的体外透皮扩散作用。方法采用Franz扩散池,以大鼠皮肤进行体外经皮渗透试验,考察丹皮酚脂质体凝胶的经皮渗透行为及皮肤内药物滞留量。结果制得的丹皮酚脂质体凝胶包封率为78.62%,平均粒径为127 nm。体外经皮渗透试验表明,与丹皮酚凝胶相比,丹皮酚脂质体凝胶透皮速率较慢,但皮肤中药物滞留量明显增加。结论丹皮酚脂质体凝胶制备工艺可行,其体外释放有明显缓释特征,有望成为丹皮酚应用的新剂型。Objective To study the transdermal diffusion action in vitro of Paeonol Liposome Gel. Methods The Franz diffusion cell was adopted and the in vitro transdermal permeation test on rat＇s skin was performed to investigate the transdermal diffusion behavior and the drug retention amount within the skin of Paeonol Liposome Gel. Results The prepared Paeonol Liposome Gel had an entrap- ment rate of 78.62% and the average particle size of 127 nm. Compared with the paeonol gel,the Paeonol Liposome Gel had lower transdermal speed, but higher drug retention amount in the skin. Conclusion The preparation process of Paeonol Liposome Gel is proved to be feasible,its in vitro release has the obvious sustained release characteristic. Paeonol Liposome Gel is hopeful to become a new formulation of paeonol application.

关 键 词：丹皮酚 脂质体 凝胶 透皮扩散 

分 类 号：R285.5[医药卫生—中药学] R286.0[医药卫生—中医学]