中国人群非小细胞肺癌GSTP1基因多态性与铂类药物敏感性Meta分析  

Meta Analysis on GSTP1 Gene Polymorphisms in Chinese Population with Non Small Cell Lung Cancer and Platinum- Based Chemotherapy Sensitivity

作　　者：邓健浩[1] 修连喜[1] 林建红[1] 

机构地区：[1]福建省龙岩市第二医院药剂科,福建龙岩364000

出　　处：《中国药业》2015年第8期53-56,共4页China Pharmaceuticals

摘　　要：目的系统评价中国人群中非小细胞肺癌（NSCLC）患者GSTP1基因多态性与铂类药物化学治疗（简称化疗）敏感性的相关性。方法计算机检索Cochrane Library,Pub Med,EMBASE数据库和中国生物医学文献数据库（CBM）、中国学术期刊全文数据库（CNKI）和中文科技期刊全文数据库维普（VIP）、万方等数据库中有关GSTP1基因多态性与铂类药物化疗敏感性的研究,由2名研究者独立筛选提取资料和评价质量,采用Rev Man 5.2软件进行Meta分析。结果有6篇文献符合要求,纳入研究,共527例患者。Meta分析结果显示,GSTP1 313 GG基因型（GG vs AA,OR为4.80,95%CI为1.57~14.69）和AG基因型（AG vs AA,OR为3.42,95%CI为1.99~5.86）的患者化疗有效率明显高于AA基因型患者,而且变异基因型G携带者（AG＋GG基因型）的化疗有效率明显高于野生型AA基因型患者（AG＋GG vs AA,OR为2.38,95%CI为1.61~3.53）。结论中国人群中非小细胞肺癌患者的GSTP1基因多态性与铂类药物化疗敏感性相关。Objective To systematically evaluate the relationship between GSTP1 gene polymorphisms in Chinese population with non-small cell lung cancer（NSCLC） and the platinum-based chemotherapy sensitivity. Methods The researches on GSTP1 gene polymor-phisms and the platinum-based chemotherapy sensitivity were retrieved from the databases of the Cochrane Library,PubMed,EMBASE, CBM,CNKI,VIP and Wangfang database. Then the extracted data were independently screened and the quality evaluation was performed by 2 researchers. The meta analysis was performed by adopting the RevMan 5. 2 software. Results A total of 6 articles meeting the requirements were included,involving 527 patients. The meta analysis results showed that the chemotherapy effective rate in the patients with genotype GSTP1 313 GG （ GG vs AA：OR,4. 80;95% CI,1. 57-14. 69 ） and genotype AG （ AG vs AA：OR,3. 42;95% CI,1. 99-5. 86 ） was significantly higher than that in the patients with gynotype AA,moreover the chemotherapy effective rate in the carrier of mutant genotype G（genotype AG＋GG）was significantly higher than that in the patients with wild genotype AA （ AG＋GG vs AA：OR, 2. 38;95% CI,1. 61-3. 53 ） . Conclusion GSTP1 gene polymorphisms is associated with the platinum-based chemotherapy sensitivity in Chinese population with NSCLC.

关 键 词：非小细胞肺癌 铂类药物 GSTP1 单核苷酸多态性 META分析 

分 类 号：R969.3[医药卫生—药理学] R979.1[医药卫生—药学]