小儿紫癜性肾炎β纤维蛋白原-455G/A基因多态性分析  

Association of FGB- 455G/A gene polymorphisms with Henoch-Schonlein purpura nephritis in children

作　　者：张晓媛[1] 方琪玮[2] 张格妙[2] 

机构地区：[1]山西医科大学儿科医学系,山西太原030001 [2]山西省儿童医院肾内科,山西太原030001

出　　处：《中国医学工程》2015年第1期1-2,共2页China Medical Engineering

摘　　要：目的探讨β纤维蛋白原(FGB)-455G/A基因多态性与小儿紫癜性肾炎(HSPN)的关系,以及时发现血浆高凝状态,尽早进行干预治疗。方法应用荧光定量PCR对70例HSPN患儿进行FGB-455G/A基因分析,常规检测血纤维蛋白原(FIB)、D二聚体(D-D)、纤维蛋白原降解产物(FDP)水平。另择20名健康儿童作对照。结果 HSPN组患儿FGB-455G/A位点GG型及G等位基因均高于对照组(P<0.05)。FGB-455G/A位点GG型儿童血FIB、D-D、FDP水平较GA+AA型明显升高(P<0.05)。结论 FGB-455G/A基因多态性与HSPN发生有关,FGB-455G/A位点GG基因型可能为HSPN的危险因素。【Objective】To explore the relationship between the fibrinogen β（FGB）- 455G/A gene polymorphism with Schonlein purpura nephritis（HSPN） in children,so as to found the hypercoagulable state, therapeutic intervention as soon as possible.【Methods】Analysis FGB-455 G /A gene polymorphism using Real-time quantitative PCR, routine test plasma fibrinogen（FIB）, D-dimer（D-D）, fibrin degradation products（FDP） levels in 70 cases of children with HSPN. 20 cases of health children as control.【Results】Children with HSPN group FGB-455G/A genetic locus GG type and G allele were higher than control group（P〈0.05）. Children with FGB-455 G /A genetic locus GG type FIB, D-D, FDP levels compared with GA ＋ AA type is increased（P〈0.05）.【Conclusion】FGB-455G/A polymorphism is associated with HSPN occurs, GG type is the possible risk factors for HSPN.

关 键 词：儿童 紫癜性肾炎 Β纤维蛋白原 基因多态性 

分 类 号：R692.34[医药卫生—泌尿科学]