治疗兔应力性骨折的实验研究  

Prevention of Stress Fracture through Application of Extracorporeal Shock Wave in Rabbits

作　　者：周忠[1] 陈振南[2] 王万明[1] 李同涛[1] 周仁强[2] 黄昌富[3] 

机构地区：[1]福建医科大学福总临床医学院骨科,福建福州350025 [2]福建中医药大学骨伤学院 [3]福建省军区福州第一干休所医疗科

出　　处：《华南国防医学杂志》2014年第9期847-850,899,共5页Military Medical Journal of South China

基　　金：南京军区医药卫生基金课题项目(2011-11MA105)

摘　　要：目的观察体外冲击波(extracorporeal shock wave,ESW)对兔应力性骨折(stress fracture,SF)中骨骼及局部肌肉组织的影响,探讨ESW治疗与SF修复的关系及作用机制。方法采用发射计算机断层扫描仪(emission computed tomography,ECT)作为诊断依据,建立兔SF模型,将12只造模成功的新西兰兔随机分为两组,冲击波治疗组(C组,n=6)、模型组(B组,n=6),同时设立正常组(A组,n=6)。C组通过ESW治疗,B、A组不进行ESW治疗,冲击波治疗后1、4、8周采用ECT及各组分别处理2只兔子进行病理切片观察,比较3组影像学、骨形态学、肌肉组织变化情况。结果 ECT扫描发现B组兔胫骨放射性计数比值显著高于C组,差异有统计学意义(P<0.05),C组胫骨放射性计数比值与A组比较也有统计学意义(P<0.05)。病理切片显示C组的骨损伤、肌肉损伤较B组明显减轻。结论冲击波可以有效治疗兔下肢SF,促进骨骼、肌肉的修复,可为临床治疗SF提供新的思路。Objective To observe the morphological changes of skeleton and skeletal muscle of rabbits, and to in- vestigate the mechanism of extracorporeal shock wave for the preventing and treating stress fracture.Methods The exper- imental model of stress fracture by emission computed tomography was established, and 12 successful model New Zeal- and rabbits were randomly divided into the treatment group of extracorporeal shock wave （C group,n = 6） and the model group（B group, n = 6） .The blank group contained 6 rabits （A group） .The morphological changes of skeleton and skeletal muscle of rabbits were determined after 1, 4, 8 weeks.Results The radio counting ratio of tibia in the model group was higher than that in treatment group and blank group （P〈0.05） , and there was difference between treatment group and blank group （P〈0.05） .The tibia injury in the model group was more serious than treatment group and blank group.Con- clusion Extracorporeal shock wave can effectively cure stress fracture of tibia in rabbits. This provides a new idea for stress fracture treatment.

关 键 词：冲击波治疗 骨闪烁显像 应力性骨折 

分 类 号：R683[医药卫生—骨科学]