新兵5km训练心肌标志物及一氧化氮变化分析  

Impact of 5 Kilometers Run on Serum Biomarkers of Cardiac Damage and Nitric Oxide in Military Recruits

作　　者：吴志峰[1] 刘扬[1] 王军[1] 李毅[1] 余研[1] 秦逸辉[1] 冯茜[1] 孙如鹏[1] 汤立功[2] 

机构地区：[1]解放军174医院干部病房 [2]73158部队卫生队

出　　处：《华南国防医学杂志》2014年第10期1000-1002,1006,共4页Military Medical Journal of South China

基　　金：南京军区医学科技资助项目(编号11MA073)

摘　　要：目的探讨新兵在日常体能训练中5km跑耐力负荷量对血清心肌损伤标志物及一氧化氮（nitric oxide,NO）的影响。方法 65名男性战士,18~20岁,分别测定5 km跑前后血清肌钙蛋白I（cardiac troponinI,cTnI）、N末端脑钠肽原（N-terminal pro-brain natriuretic peptide,NT-proBNP）和NO水平,并记录运动心率。结果运动后2 h血清cTnI升高,阳性率55.38%（范围0.010~0.162,中位数0.047）,24 h后仅一人血清cTnI略高于0.010μg/L。NT-proBNP运动后2 h明显升高,24 h后降至接近正常。运动后即刻血清NO水平增高,但与cTnI变化无相关关系。血清cTnI〉0.010μg/L者的大于最大实测心率80%运动时间明显延长（P〈0.05）。结论新兵5 km训练可以出现血清cTnI、NT-proBNP一过性升高,可能存在心肌细胞膜通透性增强或可逆性心肌损伤。血清NO水平上升未影响心肌标志物的释放。Objective To evaluate the influence of exercise endurance and intensity on the appearance of cardiac biomarkers and nitric oxide（NO）in military recruits.Method A total of 65 male military recruits took part in a 5 kilometers run.Serum cardiac troponinI（cTnI）,N-terminal pro-brain natriuretic peptide（NT-proBNP）and NO were measured before and after the run.Heart rate（HR）monitoring was also performed during the run to evaluate the exercise intensity.Results Increase of serum cTnI and NT-proBNP were observed two hours following the run,but returned towards pre-exercise level 24 hours after the run.55.38% of participants exhibited cTnI levels above 0.010μg/L and increased in prolongation of HRmax exercise.NO concentration increased significantly immediately after exercise.Conclusions The elevation of cardiac biomarkers and NO is partly associated with endurance exercise intensity.There may exist the increase of the myocardial cell membrane permeability and reversible myocardial damage.The increase of serum NO doesn＇t affect the release of myocardial markers.

关 键 词：新兵 耐力运动 心肌标志物 心肌损伤 一氧化氮 

分 类 号：R821.2[医药卫生—临床医学]