N-乙酰半胱氨酸对老年慢性阻塞性肺疾病炎性反应的影响  

Effect of N-acetylcysteine on inflammation and pulmonary function in elderly patients with chronic obstructive pulmonary disease

作　　者：李敬会[1] 蔡莉莉[1] 李丽娜[1] 

机构地区：[1]湖北医药学院附属人民医院老年病科,湖北省十堰市442000

出　　处：《实用老年医学》2015年第4期330-332,共3页Practical Geriatrics

摘　　要：目的探讨N-乙酰半胱氨酸(NAC)对老年慢性阻塞性肺疾病(COPD)患者炎性反应和肺功能的影响。方法将70例COPD患者按机械抽样法随机分为治疗组和对照组,每组35例,对照组予以常规治疗,治疗组在常规治疗基础上加用乙酰半胱氨酸泡腾片(主要成分为乙酰半胱氨酸)治疗,疗程8周。2组患者在治疗前后均行白细胞介素6(IL-6)、白细胞介素8(IL-8)和血清肿瘤坏死因子α(TNF-α)水平以及肺功能检测。结果治疗组治疗后血清IL-6、IL-8、TNF-α水平较治疗前均下降[分别为(17.45±7.22)ng/L比(29.72±6.70)ng/L、(121.28±13.26)ng/L比(150.11±15.61)ng/L、(21.33±3.92)ng/L比(33.32±8.14)ng/L],差异有统计学意义(P均<0.05),对照组治疗前后也有改变,但差异无统计学意义(P>0.05)。治疗后2组IL-6、IL-8、TNF-α水平比较差异有统计学意义(P<0.05),肺功能差异无统计学意义(P>0.05)。结论 NAC可减轻COPD炎性反应,有助于COPD的治疗。Objective To investigate the clinical therapeutic effects of N-Acetylcysteine（ NAC） on chronic obstructive pulmonary disease（ COPD） and its regulative effect on inflammation and pulmonary function. Methods Seventy patients suffering from COPD were divided into control group and treatment group by random digits table,with 35 cases in each group. Conventional therapy was administered to the two groups,and NAC was used in the treatment group additionally for 8 weeks. Interleukin-6（ IL-6）,interleukin-8（ IL-8） and tumor necrosis factor-α（ TNF-α） and pulmonary function of all patients were monitored and analyzed before and after treatment. Results The levels of IL-6,IL-8 and TNF-α were17. 45 ± 7. 22 ng / L vs 29. 72 ± 6. 70 ng / L,121. 28 ± 13. 26 ng / L vs 150. 11 ± 15. 61 ng / L,21. 33 ± 3. 92 ng / L vs 33. 32 ±8. 14 ng / L before and after treatment in the treatment group respectively,with significant differences（ P〈0. 05）,but there was no significant differences in control group（ P〉0. 05）. There were significant differences after treatment between two groups（ P〈0. 05）. Pulmonary function of two groups was of no significant difference. Conclusions NAC could inhibit inflammation and has beneficial effects on COPD.

关 键 词：乙酰半胱氨酸 慢性阻塞性肺疾病 炎性反应 肺功能 

分 类 号：R563[医药卫生—呼吸系统]