利用改进的重氮化反应法制备对氟苯甲醛的研究  

Synthesis of p- Fluorobenzaldehyde Using Diazotization Reaction

作　　者：李会勇[1] 姜小明[1] 

机构地区：[1]贵州大学化学与化工学院,贵州贵阳550025

出　　处：《有机氟工业》2015年第1期9-11,共3页Organo-Fluorine Industry

基　　金：贵州省科学技术基金(黔科合J字[2013]2097号)

摘　　要：以对甲基苯胺为主要原料,通过重氮化反应、氯代反应及水解反应制备对氟苯甲醛。重氮化反应在液化的无水氟化氢中进行,重氮盐产物可以不经分离制得对氟甲苯,可实现连续操作。重氮化反应条件为：n（亚硝酸钠）：n（对甲基苯胺）=1.2,反应温度为-10~5℃,热分解温度为40℃。在优化反应条件下重氮化反应的收率为84%,高于传统的重氮化反应。氯代反应采用过氧化苯甲酰作为催化剂,通过加热和光照使侧链的氯代反应得以顺利进行。对氟苯甲醛的总收率为69%。The p- fluorobenzaldehyde was synthesized by diazotization reaction,substitution reaction and hydrolysis,using tolidinet as the main material. The method of diazotization reaction was investigated to improve the reaction condition in the presence of HF. The optimum condition for the diazotization reaction was as follows. The mole ratio of Na NO2 and tolidinet was 1. 2. The reaction temperature of the diazotization was- 10 - 5 ℃. The decomposition temperature was 40 ℃. The recovery of the product was 84%,which is higher than that of the traditional diazotization reaction. We used benzoyl peroxide as the catalyst in the side- chain chlorination via heating and lighting. The recovery of the final product was 69% under the optimum condition.

关 键 词：合成 对氟苯甲醛 对甲基苯胺 重氮化反应 

分 类 号：TQ244.4[化学工程—有机化工]