头孢噻肟钠在不同注射液中的稳定性及抗菌活性研究  

Study on the Stability of Cefotaxime Sodium in Different Injection and Its Antibacterial Activity

作　　者：张晔[1] 徐峰[1] 吴玮峰[1] 

机构地区：[1]上海交通大学附属第六人民医院南院药剂科,上海201400

出　　处：《中国医药导刊》2014年第6期1097-1098,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:研究在一定温度条件下(35℃),头孢噻肟钠在不同注射液中的稳定性及抗菌活性。方法:采用在实验温度(35℃)下,药物在0.9%氯化钠、5%、10%葡萄糖注射液中各时间点的百分含量(C%),并且以lgC对时间t作图,并计算其降解速率常数K以及T0.9。同时配置不同注射液的头孢噻肟钠稀释液,进行抗菌活性研究。结果:在三种注射液中,0.9%氯化钠注射液能够使头孢噻肟钠更稳定存在,降解速率常数K较小。5%葡萄糖注射液中头孢噻肟钠的抗菌活性更好。结论:头孢噻肟钠的稳定性及抗菌活性与注射液种类有关,在日常使用时要注意。Objective：To Study stability and antibacterial activity of cefotaxime sodium for injection under conditions of constant temperature（35°C）.Methods：Studing the percentage content of drugs in 0.9% sodium chloride,5%,10% glucose injection at each time point under experimental temperature（35°C）,and time t plotted lgC,and calculate the degradation rate K and T0.9.and configure different injection dilutions of the cefotaxime sodium simultaneously to study the antibacterial activity.Results：In the three injections, 0.9% sodium chloride injection could make cefotaxime sodium more stable,degradation rate K is smaller,and have better antibacterial activity in 5% dextrose injection.Conclusion：Stability and antibacterial activity of cefotaxime sodium have relation to injection type,and we should pay attention to in the day-to-day use.

关 键 词：头孢噻肟钠 抗菌活性 稳定性 

分 类 号：R917[医药卫生—药物分析学]