绝经前后甲状腺功能亢进患者骨密度影响因素相关性分析  

Correlation Factors of Bone Mineral Density in Patients with Hyperthyroidism before and after Menopause

作　　者：文莉[1] 张波[2] 易念华[1] 

机构地区：[1]湖北省妇幼保健院妇女保健科,武汉430070 [2]广州军区武汉总医院呼吸内科,武汉430070

出　　处：《中国医药导刊》2014年第10期1283-1284,1287,共3页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨分析绝经前后女性甲状腺功能亢进对骨密度的影响。方法:60例甲状腺功能亢进症女性患者根据生理期不同分为甲亢A组(绝经前)与甲亢B组(绝经后),同时随机选取同地区的60例健康女性走位对照组,分别是健康A组(绝经前)与健康B组(绝经后)。测定女性甲亢患者与健康女性的骨密度,并进行比较。结果:甲亢组患者的骨密度要显著低于健康女性(P<0.05);线性回归分析结果显示:甲亢组患者的骨密度与绝经年限,病程,血清FT3水平呈负相关(P<0.05),与血清TSH水平呈正相关(P<0.05);Logistic分析结果显示:绝经年限(β=1.852,OR=6.373)、病程(β=1.629,OR=5.099)、FT3(β=1.979,OR=7.236)可能是导致女性甲亢患者并发骨质疏松的独立危险因素(P<0.05),TSH(β=-2.492,OR=0.083)是女性甲亢患者并发骨质疏松的独立保护因素(P<0.05)。结论:女性甲状腺功能亢进患者的骨密度要显著低于正常的健康女性,尤其是绝经后患者更明显,故对绝境后女性甲亢患者治疗过程中需要注意骨质疏松的发生。Objective： To study the correlation factors of bone mineral density in patients with hyperthyroidism before and after menopause.Methods：60 female patients with hyperthyroidism were divided into the hyperthyroidism A group （pre-menopausal） and hyperthyroidism B group （post-menopausal）.At the same time,60 healthy females of the same district were divided into the healthy A group （pre-menopausal） and healthy B group （post-menopausal）.The bone mineral density was tested on the patients with hyperthyroidism and the healthy females.Results：The bone mineral density of the patients with hyperthyroidism was obviously lower than the healthy females （P〈0.05）.Linear regression analysis in patients with hyperthyroidism showed that bone mineral density had negatively correlation with menopause,duration,serum FT3 levels （P〈0.05）,and had positively correlation with serum TSH （P〈0.05）;Multivariate Logistic analysis showed that menopausal years（β=1.852,OR=6.373）,the course of the disease（β=1.629,OR=5.099）,FT3（β=1.979,OR=7.236） may be the independent risk factor for hyperthyroidism female patients with osteoporosis（P〈0.05）,and TSH（β=-2.492,OR=0.083） may be the independent protective factor for hyperthyroidism female patients with osteoporosis（P〈0.05）.Conclusion：The bone mineral density of the patients with hyperthyroidism was obviously lower than the healthy females,especially after menopause were more evident.Therefore,patients with hyperthyroidism after desperate need to prevent the occurrence of osteoporosis.

关 键 词：绝经期 甲状腺功能亢进症 骨密度 

分 类 号：R581.1[医药卫生—内分泌] R711.51[医药卫生—内科学]