急性冠脉综合征合并糖尿病患者血浆hs-CRP、NT-proBNP与心功能及预后的相关性  

Relationship between hs-CRP, NT-pro BNP, LVEF and MACE in ACS Patients Complicated Diabetes

作　　者：曲华清[1] 唐强[1] 姚瑾秋 闫晓琳[1] 王硕[1] 刘坤[1] 王宏宇[1] 

机构地区：[1]北京大学首钢医院心内科,北京100141

出　　处：《中国医药导刊》2014年第11期1371-1372,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨血浆高敏C反应蛋白(hs-CRP)及B型脑钠肽(NT-pro BNP)水平与合并2型糖尿病(T2DM)的急性冠脉综合征(ACS)患者心功能及预后的相关性。方法:82例ACS,分为单纯ACS患者41例,合并T2DM患者41例;血浆hs-CRP、NT-pro BNP水平采用酶联免疫吸附法(ELISA)检测,左心室射血分数(LVEF)采用彩色超声多普勒测定,并观察3月、6月的MACE事件。结果:血浆hsCRP、NT-pro BNP水平在合并T2DM的ACS组显著高于无糖尿病(DM)组,而LVEF显著低于单纯ACS组,两组间比较差异有统计学意义(P<0.05);血浆hs-CRP、NT-pro BNP水平与LVEF呈负相关(P<0.05),与3月MACE事件呈正相关。结论:血浆hs-CRP和NT-pro BNP水平对于评价合并DM的ACS患者的心功能有一定的意义,可以预测近期预后。Objective： To investigate the relationship between high-sensitivity C-reactive protein（hs-CRP） or aminoterminal pro-brain natriuretic peptide（NT-pro BNP）and left ventricular ejection fraction（LVEF） in acute coronary syndrome（ACS） patients complicated type 2 diabetes. Methods： Serum levels of hs-CRP,NT-pro BNP at baseline were analyzed and LVEF were measured by colored doppler echocardiograph in 41 cases of simple ACS and in 41 cases of ACS complicated type 2 diabetes,and observed the MACE of all patients in 6 month. Results： In the group of ACS complicated type 2 diabetes, LVEF was lower significantly than those in the group of simple ACS,The difference was statistically significant as follows： The analysis showed that hs-CRP or NTpro BNP were related negatively to LVEF（P〈0.05） and the MACE of 3 month（P〈0.05）. Conclusions：The changes of plasma hsCRP and NT-pro BNP are significant in the evaluation of left ventricular function in ACS patients complicated DM,and can predict the prognosis of the near future.

关 键 词：急性冠脉综合征 糖尿病 高敏C反应蛋白 脑钠肽 左室射血分数 

分 类 号：R541.4[医药卫生—心血管疾病] R587.1[医药卫生—内科学]