肺炎支原体感染与儿童支气管哮喘的关系探讨  

Relation between Mycoplasma Pneumoniae Infection and Bronchial Asthma in Children

作　　者：陈金海[1] 姚明[1] 卞晓琴[1] 张金蓉[1] 

机构地区：[1]江苏省大丰市人民医院儿科,大丰224100

出　　处：《中国医药导刊》2014年第11期1387-1388,1390,共3页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨肺炎支原体(MP)感染与儿童支气管哮喘的相关性。方法:将住院治疗的100例支气管哮喘急性发作期患儿作为哮喘组,另选100例同期至本院儿科诊治的上呼吸道感染患儿作为上感组,再选50例至我院体检的健康儿童作为对照组。比较三组患儿MP-Ig M滴度以及MP-Ig M阳性率;将哮喘组患儿分为MP-Ig M阳性组(MP+组)和MP-Ig M阴性组(MP-组),比较这两组与对照组患儿之间血清总免疫球蛋白E(总Ig E)、外周血嗜酸性粒细胞(EOS)绝对值、白介素-2(IL-2)、IL-4、干扰素-γ(IFN-γ)、血清可溶性白介素-2受体(s IL-2R)、肿瘤坏死因子-α(TNF-α)以及超氧化物歧化酶(SOD)水平。结果:1哮喘组MP-Ig M滴度和阳性率均显著高于上感组和对照组(P<0.01)。2MP+组和MP-组血清总Ig E和外周血EOS绝对值均显著高于对照组,MP+组亦显著高于MP-组(P<0.01);MP+组和MP-组血清IL-2、IFN-γ和SOD水平均显著低于对照组,IL-4、s IL-2R和TNF-α显著高于对照组(P<0.01),MP+组和MP-组之间亦有显著差异(P<0.01)。结论:MP感染是诱发或加重小儿支气管哮喘的重要因素之一,它可以通过破坏Th1/Th2的动态平衡,激发气道急慢性炎症,最终引起免疫机制紊乱而致病。Objective： To explore the relation between mycoplasma pneumoniae infection and bronchial asthma in children. Methods： One hundred cases of children on acute attack of asthma acted as asthma group. 100 cases of children with upper respiratory infection at the same term acted as URI group. Another 50 cases of healthy children with physical examination acted as control group. The titer and positive incidence of MP-Ig M among three groups were compared. The children in asthma group were divided into MP-Ig M positive group（MP＋ group） and MP-Ig M negative group（MP-group）. The levels of total serum immunoglobulin E（total Ig E）, peripheral acidophilic granulocyte（EOS） absolute value, interleukin-2（IL-2）, IL-4, interferon-γ（IFN-γ）, serum soluble interleukin 2 receptor（s IL-2R）, tumor necrosis factor-α（TNF-α） and superoxide dismutase（SOD） among these two groups and control group were compared. Results： 1 The titer and positive incidence of MP-Ig M in asthma group were significantly higher than that in URI group and control group（P〈0.01）. 2 The levels of total Ig E and EOS absolute value in MP＋ group and MP-group were significantly higher than that in control group, and the l MP＋ group were significantly higher than that in MP-group（P〈0.01）. The levels of serum IL-2, IFN-γ and SOD in MP＋ group and MP-group were significantly lower than that in control group, while the levels of IL-4, s IL-2R and TNF-α were significantly higher than that in control group（P〈0.01）. There were also signicant differences between MP＋ group and MP-group（P〈0.01）. Conclusions： MP infection is one important factor of inducing or aggravating asthma in children. It may break Th1/Th2 dynamic balance, increase acute chronic respiratory tract inflammation, so as to cause immune dysfunction.

关 键 词：肺炎支原体 支气管哮喘 小儿 免疫 抗体 

分 类 号：R725.6[医药卫生—儿科]