甲磺酸帕珠沙星注射液对绿脓杆菌下呼吸道感染临床疗效观察  

Efficacy and Safety of Pazufloxacin Injection for the Treatment of Lower Respiratory Tract Infections

作　　者：罗莉[1] 

机构地区：[1]第三军医大学附属第二医院(新桥医院)呼吸科,重庆400037

出　　处：《中国医药导刊》2014年第11期1412-1413,共2页Chinese Journal of Medicinal Guide

摘　　要：目的：观察甲磺酸帕珠沙星配合常规治疗对绿脓杆菌下呼吸道感染患者临床疗效、细菌清除率、症状改善及安全性的影响。方法：将经病原学确诊的绿脓杆菌下呼吸道感染70例随机分为2组,观察组为甲磺酸帕珠沙星注射液,用药方法：300mg/次,0.9%氯化钠注射液或5%葡萄糖注射液溶解并稀释,静脉滴注,1日2次;对照组为环丙沙星,400mg/次,静脉滴注,1日2次。疗程均为7~14天。结果：观察组临床总有效率显著高于对照组（P〈0.05）;帕珠沙星治疗组症状、体征方面体温恢复、啰音消失、白细胞恢复正常的平均天数均显著少于环丙沙星对照组（P〈0.05）,咳嗽、咳痰消失天数、纸片药敏敏感率、药物细菌清除率、药物敏感率和细菌清除率相近（P〉0.05）;2组均未出现严重不良反应,但帕珠沙星对肝脏的影响、胃肠道反应均低于环丙沙星。结论：甲磺酸帕珠沙星注射液用于绿脓杆菌下呼吸道感染患者有效,安全,较环丙沙星更优。Objective： To observe the effect of pazufloxacin mesilate combined with conventional therapy on the patients with clinical efficacy, Pseudomonas aeruginosa infection of lower respiratory tract bacterial clearance rate, symptom improvement effect and safety. Methods： The 70 cases were randomly divided into 2 groups of etiological diagnosis of pseudomonas aeruginosa infection of the lower respiratory tract, the observation group of Pazufloxacin Mesilate injection, the medication methods： 300mg/ times, 0.9% sodium chloride injection or 5% glucose injection dissolved and diluted, intravenous drip, 2 times a day; the control group for ciprofloxacin, 400mg/1, intravenous infusion, 2 times a day. The treatment lasted for 7~14 days. Results： The total clinical effective rate of observation group was significantly higher than that of control group（P〈0.05）; the average length of pazufloxacin in treatment group, symptoms, signs, body temperature recovery rales disappear, the white blood cells to restore normal ciprofloxacin were significantly less than control group（P〈0.05）, cough, expectoration vanished days, disk susceptibility rate, drug sensitive bacteria clearance rate and drug sensitive rate and bacterial clearance rate was similar（P〉0.05）; the 2 groups were no serious adverse reactions, but the effect of pazufloxacin for the liver and gastrointestinal reaction were lower than those of ciprofloxacin. Conclusion： Pazufloxacin mesilate injection for pseudomonas aeruginosa in patients with lower respiratory infection is effective, safe, better than ciprofloxacin.

关 键 词：绿脓杆菌 下呼吸道感染 帕珠沙星 环丙沙星 

分 类 号：R56[医药卫生—呼吸系统]