健脾化浊方对实验性酒精性脂肪肝大鼠MDA、SOD含量的影响  

Effect of Jianpi Huazhuo formula on contents of MDA,SOD of rats with alcoholic fatty liver

作　　者：席菊兰[1] 冯明[1] 吴秋玲[1] 赵彦鹏[2] 李朝喧[1] 

机构地区：[1]山西中医学院,山西太原030024 [2]山西中医学院附属医院,山西太原030024

出　　处：《山西中医学院学报》2014年第6期25-26,共2页Journal of Shanxi College of Traditional Chinese Medicine

摘　　要：目的:探索健脾化浊方对酒精性肝病(ALD)的作用机制。方法:将54只雄性SD大鼠随机分为正常对照组、模型对照组、联苯双酯组、健脾化浊低、中、高剂量组,检测大鼠肝组织中超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量。结果:各治疗组大鼠肝组织中SOD活性均高于模型组、MDA含量均低于模型组(P<0.05)。健脾化浊方高、中、低剂量组肝组织中SOD含量均高于联苯双酯组,MDA含量均低于联苯双酯组(P<0.05)。结论:健脾化浊方对酒精性脂肪肝大鼠具有一定的治疗作用。Objective：To explore the mechanism of Jianpi Huazhuo prescription on alcoholic liver disease（ALD）. Methods：54 male SD rats were randomly divided into normal control group,model group,bifendate group,Jianpi Huazhuo low,middle and high dosage groups. Superoxide dismutase（SOD）activity and malondialdehyde（MDA）content in liver tissue of rats were detected. Results：Compared with model group,SOD activity was increased,but MDA content was decreased in treatment groups（P〈0.05）. Compared with bifendate group,SOD activity was increased,but MDA content was decreased in Jianpi Huazhuo low,middle and high dosage groups（P〈0.05）. Conclusion：Jianpi Huazhuo formula has better therapeutic effect than that of bifendate.

关 键 词：健脾化浊方 实验性酒精性脂肪肝 MDA SOD 

分 类 号：R285[医药卫生—中药学]