前列地尔脂微球载体制剂对糖尿病肾病患者血清β_2微球蛋白、血栓素B_2水平的影响  

Influence of liposome prostaglandin vector agent on levels of β_2-MG and TXB_2 in patients with diabetic nephropathy

作　　者：丁小炼 刘莲叶 

机构地区：[1]陕西省渭南市中心医院肾病内分泌科,陕西渭南714000

出　　处：《实用临床医药杂志》2015年第7期50-52,共3页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11521488)

摘　　要：目的观察前列地尔脂微球载体制剂治疗糖尿病肾病(DN)的疗效,并探讨其对血清β2微球蛋白(β2-MG)、血栓素B2(TXB2)水平的影响。方法 82例DN患者随机分为观察组42例和对照组40例,2组均给予低脂、低钠饮食,对照组给予常规治疗,观察组在此基础上加用前列地尔脂微球制剂,10μg加入20 m L生理盐水,静脉推注,1次/d,2组疗程均为4周。结果观察组总有效率显著高于对照组(P<0.05)。观察组治疗后肾功能相关指标及血清β2-MG、TXB2水平均较对照组下降显著(P<0.05或P<0.01)。结论在常规治疗基础上加用前列地尔脂微球载体制剂,可有效提高DN临床疗效,显著改善肾功能,降低血清β2-MG、TXB2水平,安全性较高。Objective To observe the clinical efficacy of liposome prostaglandin vector agent（ LPVA） in treatment of diabetic nephropathy（ DN） and to explore its influence on the levels of serumβ2microglobulin（ β2-MG） and thromboxane B2（ TXB2）. Methods A total of 82 DN patients were randomly divided into observation group（ n = 42） and control group（ n = 40）. Diet with low lipid and sodium and routine therapy was given to the control group,and on the basis of the control group,the observation group was treated with LPVA 10 μg diluted in 20 m L normal saline by intravenous injection,one time per day,4 weeks were considered as a course of treatment in both groups. Results The total clinical efficacy was evidently higher in the observation group than the control group（ P〈0.05）. Levels of renal function-associated various indexes as well as serum β2-MG and TXB2 in the observation group were significantly lower than those in the control group（ P〈0. 05 or P〈0. 01）.Conclusion On the basis of routine therapy,LPVA can effectively improve the clinical efficacy of DN patients,markedly promote the renal function and reduce the levels of β2-MG and TXB2 with high safety.

关 键 词：糖尿病肾病 前列地尔 脂微球载体 24 h尿蛋白定量 β2微球蛋白 血栓素B2 

分 类 号：R587.2[医药卫生—内分泌]