厚朴水溶性成分分离  

Water-soluble Constituents from Stem Bark of Magnolia officinalis

作　　者：卓越[1] 王建农[1] 邹本良[1] 张广德[1] 

机构地区：[1]中国中医科学院西苑医院基础医学研究所,中药药理北京市重点实验室,北京100091

出　　处：《中国实验方剂学杂志》2015年第9期39-41,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81274051)

摘　　要：目的:研究厚朴的化学成分。方法:采用硅胶,ODS柱色谱,Sephadex LH-20和半制备液相色谱等技术分离纯化,结合ESI-MS,UV,NMR等现代波谱学技术进行结构鉴定。结果:分离并鉴定了9个化合物,分别为(7S,8R)-syringoylglycerol(1),3,4-二羟基-烯丙基苯-3-O-α-L-吡喃鼠李糖(1→2)β-D-吡喃葡萄糖苷(2),3,4-二羟基-烯丙基苯-3-O-α-L-吡喃鼠李糖(1→6)β-D-吡喃葡萄糖苷(3),synapicaldehyde-4-O-β-D-glucopyranoside(4),丁香脂素双葡萄糖苷(5),3,4,5-三甲氧基苯基-β-D-葡萄糖苷(6),厚朴酚(7),和厚朴酚(8),4-O-methylhonokiol(9)。结论:化合物6为首次从厚朴中分离得到。Objective： To study the water-soluble chemical constituents from the stem bark of Magnolia officinalis. Method： The chemical constituents were isolated and purified by silica gel, ODS, Sephadex LH-20 and semi-preparative HPLC. Their structures were identified on the basis of ESI-MS, UV and NMR spectra. Result： Nine compounds were isolated and elucidated as （7S, 8R） -syringoylglycerol （1）, 3, 4-dihydroxy-allylbenzene-3- O-L-rhamnopyranosyl （ 1 →2 ） β-D-glucopyranoside （ 2 ）, 3, 4-dihydroxy-allylbenzene-3-O-L-rhamnopyranosyl （1→6） β-D-glucopyranoside （ 3 ） synapticaldehyde-4-O-β-D-glucopyranoside （ 4 ）, syringaresinol-di-O-β-D- glucopynanoside （5）, 3, 4, 5-trimethoxyphenyl-β-D-glucopyranoside （6）, magnolol （7）, honokiol （8）, 4-O- methylhonokiol （9）. Conclusion： Compounds 6 are isolated from this plant for the first time.

关 键 词：厚朴 化学成分 结构鉴定 

分 类 号：R284.1[医药卫生—中药学]