一种全新合成的抗抑郁药物的自微乳化载药系统(SMEDDS)理化性质和体外释药行为研究  

Self-microemulsifying drug delivery system(SMEDDS) for a novel medicative compound against depression: physicochemical property and in vitro release

作　　者：乌兰[1,2] 何伟[1] 赵锦花 王国成 尹莉芳[1] 

机构地区：[1]中国药科大学药学院,江苏南京210009 [2]天士力控股集团研究院化学所,天津300402

出　　处：《药学研究》2015年第4期215-218,共4页Journal of Pharmaceutical Research

基　　金：国家"十二五""重大新药创制"科技重大专项(No.2013zx09402202);天津市科技支撑计划重点项目(No.12ZCZDSY01200)

摘　　要：目的研究一种全新合成的抗抑郁药物AJS的自微乳化制剂(AJS-SMEDDS)的理化性质和体外释药行为。方法考察AJS-SMEDDS制剂的黏度、zeta电位和粒度,研究其流变学性质及电学性质;采用总体液平衡反向透析法测定其体外释药性能;并考察了其稳定性。结果 AJS-SMEDDS制剂为塑性流体,在分散介质中所形成的乳滴zeta电位为-2.76 m V,粒径为(26.08±1.68)nm,制剂质量稳定,低温不影响其性能。结论 AJSSMEDDS制剂质量稳定,适合工业生产。Objective To study the physicochemical properties and in vitro release of a self-microemulsifying drug delivery system（ SMEDDS）of AJS,the code name of an untitled novel medicative compound. Methods To study the rheo-logical properties and electrical properties of AJS-SMEDDS by examining its viscosity,zeta potential and particle size. The in vitro release of AJS-SMEDDS was examined by the bulk-equilibrium reverse dialysis bag technique. The stability of AJS-SMEDDS was also examined. Results AJS-SMEDDS was a plastic fluid with a zeta potential of -2. 76 mV and a particle size of（26. 08±1. 68）nm. The quality of AJS-SMEDDS was stable during storing period in room temperature as well as low temperature. Conclusion AJS-SMEDDS was suitable for industrial production with a stable quality.

关 键 词：自微乳化载药系统 粒径 流体 稳定性 释放 

分 类 号：R944.9[医药卫生—药剂学]