基于超分子化学的中药药性理论研究方法探讨(1)中药归经  

Study on meridian tropism of medicinal property theory for Chinese medicines by supramolecular chemistry(Ⅰ)

作　　者：贺福元[1,2,3,4] 邓凯文[5] 杨岩涛[1,2,4] 周逸群[1] 石继连[1,2,4] 刘文龙[1,2,4] 唐宇 

机构地区：[1]湖南中医药大学药学院药剂教研室,湖南长沙410208 [2]中药药性与药效国家中医药管理局重点实验室,湖南长沙410208 [3]湖南中医药大学现代中药制剂制备技术与评价实验室,湖南长沙410208 [4]湖南中医药大学中医药超分子机理与数理特征化实验室,湖南长沙410208 [5]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《中国中药杂志》2015年第8期1624-1629,共6页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81173558;81270055);国家博士点基金项目(20124323110002);湖南省自然基金项目(2015JJ2111);湖南省教育厅重点项目(14A108);湖南省教育厅十二五药学重点学科项目

摘　　要：在超分子化学对中医药基本理论特殊影响研究的基础上,进一步分析中药归经的历史沿革、中药生物体的自然本源,阐述中药成分群与人体经络脏腑的超分子"印迹模板"空穴通道结构自主作用的普遍规律:作为天然超分子"印迹模板"聚集体的中药,进入人体后,必然寻找到与自身"印迹模板"相吻合的人体经络脏腑的超分子主体发生自识别、自组织、自组装与自复制作用,从而产生针对经络脏腑的特异性药效,宏观上表现出中药归经现象。这种作用规律可采用体外、体内实验方法进行研究,体外方法主要采用超分子化学结构分析、动力学与热力学参数测算方法;体内研究方法主要采用客体成分分布、谱效动力学参数、网络谱效动力学参数分析方法,其中穴药法能化简超分子主客体关系的研究。因此,中药归经是揭示自然界生物体主客体大小分子按"印迹模板"相互交流的普遍规律,是阐明中医药理论物质基础的第一道屏障,是实现中医药基础理论现代化的突破口,在中医药基础理论研究中占有非常重要地位。In this paper, based on the special influence of supramolecular chemistry on the basic theory of Chinese medicines （ CM）, the authors further analyzed the history of meridian tropism and natural origins of CM organisms and explained CM ingredients and the universal regularity of the automatic action of the supramolecular ＂imprinting templates＂ hole channel structure. After entering human bodies, CMs, as the aggregation of supramolecular ＂imprinting templates＂, automatically seek supramolecular subjects that are matched with their ＂imprinting templates＂ in human meridians and organs for the purpose of self-recognition, self-organization, self-as- sembly and self-replication, so as to generate specific efficacy in meridians and organs, which is reflected as the meridian tropism phe- nomena at macro level. This regularity can be studied by in vitro and in vivo experimental studies. In vitro methods are mostly supra mo- lecular structure analysis and kinetic and thermodynamic parameter calculation; Whereas in vivo methods are dominated by the analysis on object component distribution, chromatopharmacodynamic parameters and network chromatopharmacodynamie parameters; Particu- larly, the acupoint-medicine method can simplify to study the supramolecular subject-object relations. Consequently, CM＇s meridian tropism reveals the universal regularity for interactions of macromolecular and micromolecular ＂ imprinting templates＂ of subjects and objects in natural organisms. As the first barrier for the material base of the CM theory and breakthrough in the modernization of the basic CM theory, meridian tropism plays an important role in studies on basic theories of the basic CM theory.

关 键 词：中药 超分子化学 归经 中医药基础理论 物质基础 气析 中药药理学 中医药现代化 经络脏腑 数理特征化 分 子拓扑学 分子连接性指数 

分 类 号：R285.1[医药卫生—中药学]