乌司他丁联合参麦注射液治疗急性胰腺炎疗效观察  

Clinlical observation of combined application of Ulinastin and Shenmai injection in treating acute pancreatitis

作　　者：赵洪涛[1] 张占云[1] 王栋[1] 

机构地区：[1]保定市第二医院普通外科,河北省071051

出　　处：《中华普外科手术学杂志（电子版）》2015年第2期48-50,共3页Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)

摘　　要：目的通过本课题研究以乌司他丁单独及联合应用参麦注射液治疗急性胰腺炎,比较轻型和重症急性胰腺炎患者单独和联合用药的疗效。方法选取2010年至2013年间收治的急性胰腺炎患者80例,其中轻型40例,重症40例,随机分为两组:实验组(轻重型各20例)联合用药治疗,对照组(轻重型各20例)单独应用乌司他丁治疗。所有的资料录入Excel数据库,应用SPSS13.0统计软件,治疗前、后血尿淀粉酶、血常规和生化各指标均数用x珋±s表示,采用t检验;有效率的比较采用χ2检验,P<0.05表示有统计学意义。结果轻型急性胰腺炎的治疗中,两组治疗前后差异无统计学意义(P>0.05)。重症急性胰腺炎患者治疗后血淀粉酶[实验组(128.1±73.6)mmol/L,对照组(412.7±123.3)mmol/L],尿淀粉酶[实验组(102.2±51.3)mmo L/L,对照组(218.2±83.3)mmol/L]、血WBC[实验组(8.3±2.2)×109/L,对照组(12.6±2.4)×109/L]、谷草转氨酶[实验组(31.3±10.1)U/L,对照组(72.4±11.2)U/L]各组指标均数对比(t=2.528、3.527、3.021、3.122,P<0.05),实验组效果优于对照组,差异均有统计学意义(P<0.05)。重症急性胰腺炎联合用药疗效较单独应用乌司他丁疗效好,实验组总有效率为95.0%,对照组总有效率为60.0%,差异有统计学意义(χ2=7.03,P=0.02)。结论对于轻型急性胰腺炎单纯应用乌司他丁即可获得满意疗效,对于急性重症胰腺炎,乌司他丁与参麦注射液联合应用可控制病情的发展、提高治愈率,有重要临床意义,值得推广。Objective To investigate the clinical effects of Ulinastin and Shenmai injection in treating acute pancreatitis. Methods From 2010 to 2013, 80 patients with acute pancreatitis were randomly divided two groups ： experimental group （20 patients with mild acute pancreatitis, 20 patients with severe acute pancreaitis ） and control group （20 cases of mild acute pancreaitis, 20 cases of severe acute pancreaitis）. The patients in the experimental group received combined therapy of Ulinastin and Shenmai injection, while patients in the control group received Ulinastin only. Clinical data were collected into EXCEL database and analyzed by using SPSS13. 0 software. Measurement data including pre/post-operative blood and urinary amylase, WBC and ALT were compared between the two groups by Student＇s t test. The curative rate of the patients was evaluated by the chi-square test. P 〈 0.05 was considered statistically significant. Results No significant difference was observed in patients with mild acute pancreaitis between the two groups （ P 〉 0.05）. In patients with severe acute pancreaitis, however, significant difference was observed between the two groups, in blood amylase [ exprerimental group（ 128.1 ±73.6） mmol/L vs control group （412.7 ±123.3 ） mmol/L], urine amylase [ exprerimental group （102.2 ± 51.3） mmol/L vs control group （218.2 ± 83.3 ） mmol/L], WBC [ exprerimental group （ 8. 3 ± 2. 2 ） x 109/L vs control group （12.6 ± 2. 4 ） × 10^9/L ], AST [ exprerimental group （31.3 ± 10.1 ） U/L vs control group （72.4 ± 11.2） U/L ] （ t = 2. 528, 3. 527, 3. 021, 3. 122 respectively, P 〈 0.05）. While the curative rate of combined therapy in treating patients with severe acute pancreatitis was 95.0% in the exprerimental group compared with 60.0% in the control group （χ2 =7.03, P = 0. 02 ）. Conclusions For patients with mild acute pancreaitis, Ulinastin could produce satisfactory effects. However, the combination of Ulinastin and Shenmai injection could effecti

关 键 词：胰腺炎 急性坏死性 治疗结果 对比研究 乌司他丁 参麦注射液 

分 类 号：R657.51[医药卫生—外科学]