阿托伐他汀钙降低运动高血压反应和改善运动耐量的临床研究  

Effect of atorvastatin on decreasing a hypertensive response to exercise and improving exercise tolerance

作　　者：叶萍贞 叶萍仙 朱建华[2] 高丹忱[2] 

机构地区：[1]金华广福医院心内科,浙江金华321000 [2]浙江大学医学院附属第一医院心内科,杭州310031

出　　处：《中国临床药理学杂志》2015年第8期599-602,611,共5页The Chinese Journal of Clinical Pharmacology

基　　金：金华市自然科学基金资助项目(2010-3-028)

摘　　要：目的评价阿托伐他汀钙对左心室舒张功能不全合并运动高血压患者运动血压及运动耐量的影响。方法选择左心室舒张功能不全并运动高血压患者60例随机分成治疗组30例和对照组30例。2组患者原治疗方案(降压及抗血小板治疗等)继续,治疗组加用阿托伐他汀钙20 mg,口服,每晚1次,对照组加用外形相同的安慰剂,疗程1年。2组治疗前后均进行运动心肺功能检查、运动血压测定和生活质量评定。结果治疗后,治疗组静息收缩压、脉压、运动最大收缩压降低,运动时间、运动当量、运动最大摄氧量、无氧阈值增大,生活质量评分改善,各指标相比治疗前差异均有统计学意义(P<0.05);其与对照组治疗后的静息收缩压、运动最大收缩压、运动时间比较,差异有统计学意义(P<0.05)。结论阿托伐他汀钙治疗能有效降低左心室舒张功能不全并运动高血压患者的血压及运动最大收缩压,改善运动耐量,提高生活质量。Objective To evaluate the effect of atorvastatin on exercise blood pressure and exercise tolerance of patients with diastolic dysfunction and hypertensive responses to exercise.Methods Sixty patients with diastolic dysfunction and hypertensive responses to exercise were selected and divided randomly into atorvastatin treatment group（n = 30,atorvastatin 20 mg qn） and control group（n = 30）.All patients continued their original therapy.The course of treatment was one year.The data of cardiopulmonary exercise testing,exercise blood pressure measurement,quality of life assessment using heart failure questionnaire were compared before and after treatment.Results After treatment,the resting systolic blood pressure,pulse pressure,and the peak exercise systolic blood pressure were significantly decreased,and exercise time,metabolic equivalent（METs）,maximal oxygen uptake（VO2max） and anaerobic threshold（AT） were increased,and and quality of life were improved compared with before treatment（P〈0.05）.There was statistical difference in the resting systolic blood pressure,the peak exercise systolic blood pressure,and the exercise time between two groups found（P〈0.05）.Conclusion For patients with diastolic dysfunction and a hypertensive response to exercise,atorvastatin can effectively reduce the blood pressure and peak exercise systolic bloodpressure,increase exercise tolerance and improve quality of life.

关 键 词：阿托伐他汀 舒张功能不全 左心室 运动高血压 运动耐量 

分 类 号：R972.6[医药卫生—药品] R969.4[医药卫生—药学]