血清胱抑素C和β2-微球蛋白检测在糖尿病肾病早期诊断的应用价值  

The diagnostic value of Cystatin C and β2-microglobulin to early diagnosis of diabetic nephropathy

作　　者：肖家凤 罗建蓉[1] 吕锦春 黎浩[1] 封磊[1] 

机构地区：[1]邛崃市医疗中心医院检验科,四川邛崃611530

出　　处：《中国实验诊断学》2015年第4期561-563,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨血清胱抑素C和β2-微球蛋白检测在糖尿病肾病早期诊断的应用价值。方法选取2011年5月—2014年5月我院收治的糖尿病肾病患者200例为研究组,另选取健康体检者200例为对照组,采用循环酶法和乳胶增强免疫比浊法检测两组对象的血清胱抑素C、β2-微球蛋白、尿素和肌酐水平。结果研究组血清胱抑素C、β2-微球蛋白、肌酐和尿素水平均显著高于对照组,两组比较差异具有统计学意义(P<0.05);糖尿病肾病II期、III期和IV期患者血清胱抑素C、β2-微球蛋白水平有递增趋势,且均显著高于I期者,与I期比较差异具有统计学意义(P<0.05)。结论血清胱抑素C、β2-微球蛋白检测在糖尿病肾病早期诊断中具有重要价值,可为临床诊断和治疗提供依据。Objective To study the diagnostic value of Cystatin C andβ2-microglobulin to early diagnosis of diabetic nephropathy.Methods 200 cases （the study group）with diabetic nephropathy were selected from our hospital during the period from May 2011 to May 2014,200 cases （the control group）of healthy were also selected,the Cystatin C andβ2-microglobulin levels of two groups were detected in enzymatic cycle and latex-enhanced turbidimetric immunoassay, and detected the urea and creatinine levels.Results Levels of Cystatin C,β2-microglobulin,creatinine and urea of the study group were significantly higher than the control group,the difference was statistically significant （P 〈 0.05）;Cystatin C andβ2-microglobulin levels of diabetic nephropathy II,III,IV period was increasing trend,and were significantly higher than Phase I,the difference was statistically significant （P 〈0.05）.Conclusion Cystatin C andβ2-microglobulin had a certain value to diagnosis of diabetic nephropathy,can provide the basis for clinical diagnosis and treatment.

关 键 词：血清胱抑素C Β2-微球蛋白 糖尿病肾病 诊断 

分 类 号：R587.2[医药卫生—内分泌]