阿昔洛韦治疗传染性单核细胞增多症的临床效果评价  

Evaluation of the clinical effect of acyclovir in the treatment of infectious mononucleosis

作　　者：钟乐璇[1] 唐普润[1] 胡湘[1] 

机构地区：[1]广州医科大学附属第二医院儿科,广东广州510260

出　　处：《吉林医学》2015年第10期1949-1950,共2页Jilin Medical Journal

摘　　要：目的:评价阿昔洛韦治疗传染性单核细胞增多症的临床效果。方法:根据纳入/排除标准共选取83例病例作为本次研究对象并随机分组;对照组给予常规对症处理,研究组给予常规对症处理加阿昔洛韦治疗;比较两组患儿体温恢复正常、淋巴结肿大消失、咽峡炎症状消失、异型淋巴细胞﹤10%及住院时间及治疗期内不良反应发生情况。结果:研究组患儿体温恢复正常、淋巴结肿大消失、咽峡炎症状消失、异型淋巴细胞﹤10%及住院时间值依次为(4.1±1.3)d、(6.7±2.8)d、(6.8±2.0)d、(8.4±4.5)d、(9.2±2.6)d,均较对照组明显缩短,差异有统计学意义(P﹤0.05);两组治疗期内均未发生明显不良反应,均按预定计划完成治疗。结论:阿昔洛韦治疗传染性单核细胞增多症的临床效果较佳,可有效缓解患儿发热、淋巴结肿大、咽峡炎等临床症状,促进患儿早期恢复,避免发生严重并发症,值得临床推广应用。Objective To evaluate the clinical effect of acyclovir in the treatment of infectious mononucleosis. Method According to the inclusion / exclusion criteria 83 cases were selected as the research object and randomly divided into two groups;the control group was given routine symptomatic treatment plus ribavirin therapy,the study group was given conventional treatment and acyclovir treatment the temperature returned to normal,lymphadenopathy disappeared,angina symptoms,atypical lymphocytes ﹤ 10% and in hospital time and treatment period and adverse reaction in two groups were compared. Results The study group with the temperature returned to normal,lymphadenopathy disap-peared,angina symptoms,atypical lymphocytes ﹤ 10% and hospitalization time values were（4. 1 ± 1. 3）d（,6. 7 ± 2. 8）d（,6. 8 ± 2. 0） d（,8. 4 ± 4. 5）d（,9. 2 ± 2. 6）d,mean significantly shorter than the control group,there was significant difference（ P﹤0. 05）;treatment in the two groups were no obvious adverse reactions,completed the treatment according to schedule. Conclusion The clinical effect of acyclov-ir in the treatment of infectious mononucleosis syndrome is better,can effectively alleviate children,fever,swollen lymph nodes,go far angina symptoms,promote early recovery of children,to avoid serious complications. It is worthy of clinical application.

关 键 词：阿昔洛韦 传染性单核细胞增多症 临床效果 

分 类 号：R512.7[医药卫生—内科学]