针刺配合药物干预肥胖型多囊卵巢综合征临床观察  

Clinical Observation of Acupuncture plus Medication for Obesity-type Polycystic Ovary Syndrome

作　　者：陈明[1] 张花[2] 张迎春[2] 

机构地区：[1]武汉市中西医结合医院,武汉430022 [2]湖北省妇幼保健院,武汉430072

出　　处：《上海针灸杂志》2015年第4期310-313,共4页Shanghai Journal of Acupuncture and Moxibustion

摘　　要：目的观察针刺配合中药及炔雌醇环丙孕酮治疗肥胖型多囊卵巢综合征患者不孕的临床疗效。方法将经过系统检查符合本研究的门诊患者100例,据就诊顺序按随机数字表分为治疗组、对照组。两组均口服炔雌醇环丙孕酮治疗3个月后,治疗组用中药加针刺治疗,西药组用口服二甲双胍、氯米芬及肌肉注射促性腺激素(HMG)和人绒毛膜促性腺激素(HCG)治疗,疗程3个月。治疗前及治疗后3个月检测血清性激素,包括促卵泡生成素(FSH)、黄体生成激素(LH)、睾酮(T)、雌二醇(E2)、泌乳素(PRL);空腹血糖、糖耐量以及胰岛素释放;排卵率、妊娠率以及总有效率。结果治疗后组间比较,LH、LH/FSH、排卵率、卵泡刺激综合征发生率的差异均有统计学意义(P<0.05);糖代谢、胰岛素的释放、综合疗效、优势卵泡数和妊娠率的差异无统计学意义(P>0.05)。组内比较,治疗组LH、LH/FSH水平,对照组LH、LH/FSH水平,排卵率、优势卵泡数差异均有统计学意义(P<0.05),妊娠率及卵泡刺激综合征发生率均无统计学意义(P>0.05)。结论针刺配合中药及炔雌醇环丙孕酮综合疗法能下调LH、LH/FSH,提高排卵率,且不易引起卵泡刺激综合征。Objective To obsrve the clinical efficacy of acupuncture, herbal medicine, plus Ethinylestradiol and Cyproterone Acetate tablets in treating infertility due to obesity-type polycystic ovary syndrome（PCOS）. Method A hundred elegible patients were divided into a treatment group and a control group according to their visiting sequence and random number table. The two groups both received oral administration of Ethinylestradiol and Cyproterone Acetate tables for 3 months. Afterwords, the treatment group was given Chinese herbal medication and acupuncture, while the control group received oral administration of Metformin and Clomiphene plus muscular injection of human menopausal gonadotropin（HMG） and human choionic gonadotropin（HCG）. Both groups received a 3-month course. Before and 3 months after the intervention, serum sex hormones were detected, including： follicle-stimulating hormone（FSH）, luteinizing hormone（LH）, testosterone（T）, estrodiol（E2）, and prolactin（PRL）; fasting sugar, sugar tolerance, and insulin release were measured; ovulation, pregnance rate, and total effective rate were calculated. Result After intervention, there were significant differences in comparing LH, LH/FSH, ovulation, and the incidence of follicle hyperstimulating syndrome between the two groups（P0.05）; there were no significant differences in comparing sugar metabolism, insulin release, comprehensive efficacy, dominant follicle count, and pregnancy rate（P0.05）. After intervention, the LH and LH/FSH levels were significantly changed in the treatment group, while the LH and LH/FSH levels, ovulation, and dominant follicle count were significantly changed in the control group（P0.05）, but pregnancy rate and follicle hyperstimulating syndrome were insignificantly changed in both groups（P0.05）. Conclusion Combination of acupuncture, Chinese herbal medicine, and Ehinylestradiol and Cyproterone Acetate tablets can down-regulate the LH and LH/FSH levels, and enhance ovulation, without causing foll

关 键 词：针刺 针药并用 多囊卵巢综合征 不育 女性 

分 类 号：R246.3[医药卫生—针灸推拿学]