血液灌流联合环磷酰胺治疗百草枯中毒患者的临床疗效  

Clinical Efficacy of Hemoperfusion Therapy Combined with Cyclophosphamide for Patients with Paraquat Poisoning

作　　者：王晋鹏[1] 郑保健[1] 翁银燕[1] 黄新文[1] 

机构地区：[1]浙江省立同德医院,杭州310012

出　　处：《中国现代应用药学》2015年第4期504-507,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的探讨血液灌流(hemoperfusion,HP)联合环磷酰胺治疗百草枯中毒患者的临床疗效。方法将64例百草枯中毒患者随机分为HP组与联合治疗组,HP组在常规治疗的基础上给予血液灌流治疗,联合治疗组在HP组治疗基础上加用环磷酰胺。治疗3周后观察2组患者白细胞、血肌酐、血谷丙转氨酶、血肌酸激酶、肝功能、肾功能、病死率、死亡患者存活时间等指标的变化。结果治疗3周后联合治疗组白细胞、血肌酐、血谷丙转氨酶、血肌酸激酶、死亡率、肺功能障碍、肾功能障碍、中毒性心肌炎及MODS均低于HP组,差异具有统计学意义(P<0.05),联合治疗组死亡病例存活时间高于HP组,差异具有统计学意义(P<0.05)。结论 HP联合环磷酰胺治疗百草枯中毒患者的疗效确切,值得临床推广。OBJECTIVE To explore the clinical efficacy of hemoperfusion therapy combined with cyclophosphamide in the treatment of patients with paraquat poisoning. METHODS Sixty-six patients of paraquat poisoning were randomly divided into HP group and combination therapy group. The patients of the HP group were treated by hemoperfusion therapy, while the combination therapy groups were treated by hemoperfusion therapy combined with cyclophosphamide. The white blood cells, serum creatinine, serum glutamic pyruvic transaminase, serum creatine kinase, liver and kidney function, mortality and survival time of the death were ompared in two groups. RESULTS The white blood cells, serum creatinine, serum glutamic pyruvic transaminase, serum creatine kinase, liver and kidney function and mortality of hemoperfusion therapy combined with cyclophosphamide were lower than hemoperfusion therapy only. The differences were statistically significant（P0.05）. The survival time of the death of hemoperfusion therapy combined with cyclophosphamide were higher than hemoperfusion therapy only. The differences were statistically significant（P0.05）. CONCLUSION For the treatment paraquat poisoning, the clinical efficacy of hemoperfusion therapy combined with cyclophosphamide is satisfied, which is worthy of promoting.

关 键 词：环磷酰胺 百草枯 临床疗效 

分 类 号：R969.4[医药卫生—药理学]